Stage

Seymour's first professional activity as an entertainer came with the Jitney Players, for which she earned $15 per week.^[4]

She was in four Broadway productions. She played in At the Bottom and Puppet Show, both in 1930, and in The School for Scandal in 1931. Almost three decades later, she played Mrs. Sara Delano Roosevelt in Sunrise at Campobello.^[6]

Radio

Seymour debuted on radio in Cincinnati in 1932.^[4] According to the 06/25/1938 issue of WLS Radio's "Stand By" magazine Seymour was living in the north side of Chicago. In the early 1940s, she played Prudence Dane, the leading female role in the "historic serial" A Woman of America^[4] and starred as Mary Marlin in The Story of Mary Marlin, both on NBC.^[3] She was also a member of the casts of Joyce Jordan, Girl Interne; Tom Bradley; Against the Storm; and King Arthur, Junior.^[7]

Television

Seymour's first venture in television was a three-month role in Follow Your Heart, an NBC soap opera. "I hated every minute of it," she said.^[8] She also "had a running part on a CBS soap opera called The First Hundred Years."^[8] She played Mrs. Barr in season 1, episode 15 of My Three Sons in 1961. She later starred in Empire, a 1962–63 series set in the modern American West.^[8] Turning her talents to comedy, she was a regular on The Tim Conway Show in 1970.^[9]

She was a guest star on many American television series in the 1960s and 1970s. She appeared in two episodes of Perry Mason; in 1963 she played Hettie Randall in "The Case of the Festive Felon", and in 1964 she played Bonnie Mae Wilmet in "The Case of the Bullied Bowler". She portrayed Amelia Tarbell in Pollyanna (1960), Esther in the episode "Final Escape" of Alfred Hitchcock Presents (1985), and Miss Tilford in A Tree Grows in Brooklyn. In a 1965 episode of Hazel entitled "A 'Lot' to Remember", she played Laura Kirkland. In 1966 she was a guest star in season 3, episode 11 of Bewitched.

She played Ms. Frost in "A Visit to Upright", a 1972 episode of Bonanza, as well as three different characters in four episodes of Gunsmoke: "Snow Train Parts 1 & 2", "The Wake", and "Kitty's Injury". In the spring of 1970, she was a regular cast member of the situation comedy The Tim Conway Show, playing airport and airline owner Mrs. K. J. Crawford during the show's 12-episode run. She guest-starred in the episode "Involvement" of Emergency! that first aired on January 24, 1976 (Season 5, Episode 17). She played the role of Millie Eastman, a retired head nurse of Rampart General who tried to commit suicide by overdosing on pills. During her recovery at Rampart, she is placed in a semi-private room with Jean Clark (Dawn Lyn) whom she starts mentoring for emotional support.

Film

An early film appearance by Seymour was in All the King's Men (1949) as Mrs. Lucy Stark.^[10] She played the role of Grandma Beebe in the 1961 children's film classic Misty, a screen adaptation of Marguerite Henry's children's book, Misty of Chincoteague.^[10][11] Her last performance was in 1988, in the feature film Field of Dreams, which was released after her death.^[10]