Acting

Cusack starred in her first film role in 1992, when she was cast in A League of Their Own, as Shirley Baker. She was in the 1996 comedy Multiplicity, which starred Michael Keaton and Andie MacDowell. Also in 1996, she replaced Anita Barone on The Jeff Foxworthy Show until the series ended. In 1998, Cusack starred in Maggie on Lifetime Television.

Cusack has made guest appearances in Grey's Anatomy, Scandal, One Tree Hill, Charmed, Ghost Whisperer, The Unit, Boston Legal, Bones, Frasier, Ally McBeal, Criminal Minds, Private Practice, and Castle among others. In 2002, she guest-starred in the episode of Star Trek: Enterprise entitled "Carbon Creek". She had a small role in Grosse Pointe Blank, which starred her siblings John and Joan; appeared in the movie Accepted, in which she plays Diane Gaines, mother to the lead character played by Justin Long; and appeared in the film What Planet Are You From?. She also co-starred in Ace Ventura Jr: Pet Detective as Melissa Robinson Ventura, the titular character's mother (replacing Courteney Cox from the original film).

She also appeared in the SciFi series Lost Room as Helen Ruber (two episodes, 2006). In 2015, she appeared in the first episode of Fargo's second season. In 2016, she played Donna Dent in the Clint Eastwood-directed Warner Bros. film Sully, about Chesley Sullenberger and the events of Flight 1549, starring Tom Hanks. She also made her first appearance as Rebecca Bois, Chuck's ex wife, in season two of Better Call Saul, later returning in season three.^[9][10]

Musical career

In August 2021, Cusack formed the musical group entitled, "Ann Cusack and the Generation Jones Band" which she is the lead singer.^[11][12][13]

Film

Television