Animal_models_of_epilepsy

Animal models of epilepsy

Animal models of epilepsy

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Animal models of epilepsy have helped to advance the understanding of how normal brains develop epilepsy (a process known as Epileptogenesis), and have been used in pre-clinical trials of antiepileptic drugs.[1] Epilepsy is a set of syndromes which have in common a predisposition to recurrent epileptic seizures.[2] Animal models of epilepsy and seizures can be divided into three basic categories: genetic animal models, chemically induced models, and electrically induced models.[3] New models are using light-gated ion channels to turn on cell firing and these are part of optogenetic induction models of epilepsy.[4]

References

  1. [1]
    Sarkisian, Matthew R. (31 May 2001). "Overview of the Current Animal Models for Human Seizure and Epileptic Disorders". Epilepsy & Behavior. 2 (3): 201–216. doi:10.1006/ebeh.2001.0193. PMID 12609365.
  2. [2]
    Chang, Bernard S.; Lowenstein, Daniel H. (25 September 2003). "Epilepsy". New England Journal of Medicine. 349 (13): 1257–1266. doi:10.1056/NEJMra022308. PMID 14507951.
  3. [3]
    Löscher, Wolfgang (31 May 2011). "Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs". Seizure. 20 (5): 359–368. doi:10.1016/j.seizure.2011.01.003. PMID 21292505. Retrieved 1 August 2012.
  4. [4]
    Cela, Elvis; McFarlan, Amanda R.; Chung, Andrew J.; Wang, Taiji; Chierzi, Sabrina; Murai, Keith K.; Sjöström, P. Jesper (March 27, 2019). "An Optogenetic Kindling Model of Neocortical Epilepsy". Scientific Reports. 9 (1): 5236. doi:10.1038/s41598-019-41533-2. ISSN 2045-2322. PMC 6437216. PMID 30918286.
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