Amino_acid_transporter
An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.
There are several families that function in amino acid transport, some of these include:
- TC# 2.A.3 - Amino Acid-Polyamine-Organocation (APC) Superfamily
- TC# 2.A.18 - Amino Acid/Auxin Permease (AAAP) Family
- TC# 2.A.23 - Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
- TC# 2.A.26 - Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
- TC# 2.A.42 - Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
- TC# 2.A.78 - Branched Chain Amino Acid Exporter (LIV-E) Family
- TC# 2.A.95 - 6TMS Neutral Amino Acid Transporter (NAAT) Family
- TC# 2.A.118 - Basic Amino Acid Antiporter (ArcD) Family
- TC# 2.A.120 - Putative Amino Acid Permease (PAAP) Family
- (1) high affinity glutamate and neutral amino acid transporter[1]
- (3) heavy subunits of heteromeric amino acid transporters[2]
- (6) Bacterial Leucine Transporter (LeuT)[3]
- (7) cationic amino acid transporter/glycoprotein-associated[4]
- (15) proton oligopeptide cotransporter[5]
- (17) vesicular glutamate transporter[6]
- (18) vesicular amine transporter[7]
- (25) some mitochondrial carriers[8]
- (26) multifunctional anion exchanger[9]
- (32) vesicular inhibitory amino acid transporter[10]
- (36) proton-coupled amino acid transporter[11]
- (38) System A & N, sodium-coupled neutral amino acid transporter[12]
VIAAT
Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.[13]
SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6.
- Singh SK, Piscitelli CL, Yamashita A, Gouaux E (2008). "A competitive inhibitor traps LeuT in an open-to-out conformation". Science. 322 (5908): 1655–1661. Bibcode:2008Sci...322.1655S. doi:10.1126/science.1166777. PMC 2832577. PMID 19074341.
- Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Arch. 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310. S2CID 11670040.
- Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Arch. 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358. S2CID 20764857.
- [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003