Alan_Brash_(pharmacologist)

Alan Brash (pharmacologist)

Alan Brash (pharmacologist)

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Alan Richard Brash (born 1949) is a professor of pharmacology at Vanderbilt University.[1] He is a leading authority on the biosynthesis of prostoglandins and eicosanoids.[1]

Biography

Education

Brash was educated at Strathallan School near Perth, Scotland and Downing College, Cambridge, where he was elected a scholar.[2] He graduated with a BA in medical sciences in 1970 and proceeded to the University of Edinburgh to study for his PhD, graduating in 1976.[3] Brash was then appointed a research fellow in the Department of Clinical Pharmacology at the Royal Postgraduate Medical School in London.[3] Thereafter, he moved to Vanderbilt University.[3]

Research

During his time at Vanderbilt, Brash's research has focused on the analysis of the mechanisms of formation and transformation of lipoxygenase products with an interest in their physiological role.[3] His findings have initiated further research on stereochemical aspects of lipoxygenase catalysis and on the role of epithelial lipoxygenases.[3]

Furthermore, his research has led to more work on the biochemistry of the CYP74 family of cytochrome P450s, and on the catalase-related hemoproteins which also metabolize fatty acid hydroperoxides.[3] As of 2023, he had published more than 250 research papers.[4]

In October 2013 he was elected a Fellow of the American Association for the Advancement of Science.[5]

References

  1. [1]
    "Vanderbilt celebrates 18 elected fellows of the AAAS". Vanderbilt University. 25 November 2013. Retrieved 29 October 2015.
  2. [2]
    "A R Brash" (PDF). The Strathallian. Vol. 9, no. 3. Autumn 1970. p. 13. Archived from the original (PDF) on 17 November 2015. Retrieved 29 October 2015.
  3. [3]
    Brash, Alan R (September 2009). "Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes". Phytochemistry. 70 (13–14): 1522–1531. Bibcode:2009PChem..70.1522B. doi:10.1016/j.phytochem.2009.08.005. PMC 2783490. PMID 19747698.
  4. [4]
    Alan R. Brash author entry at OpenAlex
  5. [5]
    "AAAS Members Elected as Fellows". Science. 342: 1064. 29 November 2013. doi:10.1126/science.342.6162.1062.

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