Adipocyte_protein_2

adipocyte protein 2

adipocyte protein 2

Protein-coding gene in the species Homo sapiens

aP2 (adipocyte Protein 2)[5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs[6] has the possibility of treating heart disease and the metabolic syndrome.[7]

Quick Facts FABP4, Available structures ...

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000170323 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000062515 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID 2481498.
  6. [6]
    Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi:10.1016/j.ejmech.2017.07.022. PMID 28738306.
  7. [7]
    Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. Journal of Atherosclerosis and Thrombosis. 26 (3): 216–232. doi:10.5551/jat.48710. PMC 6402888. PMID 30726793.
  • FABP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte



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