V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.^[5][6]

Quick Facts Identifiers, Aliases ...

ATP6V1D
Identifiers
Aliases	ATP6V1D, ATP6M, VATD, VMA8, ATPase H+ transporting V1 subunit D
External IDs	OMIM: 609398; MGI: 1921084; HomoloGene: 5783; GeneCards: ATP6V1D; OMA:ATP6V1D - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 67,294,371 bp[1] End 67,360,265 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C3|12 35.51 cM Start 78,887,499 bp[2] End 78,908,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 pons lateral nuclear group of thalamus prefrontal cortex Brodmann area 9 Pars compacta kidney tubule superior vestibular nucleus Top expressed in motor neuron facial motor nucleus substantia nigra nucleus accumbens temporal lobe amygdala prefrontal cortex retinal pigment epithelium cingulate gyrus Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase-coupled transmembrane transporter activity protein binding proton-transporting ATPase activity, rotational mechanism Cellular component cytosol centrosome membrane cilium lysosomal membrane proton-transporting V-type ATPase complex extracellular exosome plasma membrane specific granule membrane Biological process insulin receptor signaling pathway transferrin transport ion transport ion transmembrane transport cell projection organization protein localization to cilium regulation of macroautophagy phagosome acidification neutrophil degranulation cilium assembly transport proton transmembrane transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51382 73834 Ensembl ENSG00000100554 ENSMUSG00000021114 UniProt Q9Y5K8 P57746 RefSeq (mRNA) NM_015994 NM_023721 RefSeq (protein) NP_057078 NP_057078.1 NP_076210 Location (UCSC) Chr 14: 67.29 – 67.36 Mb Chr 12: 78.89 – 78.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.^[6]