The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.^[5][6][7]

Quick Facts ATP5F1C, Identifiers ...

ATP5F1C
Identifiers
Aliases	ATP5F1C, ATP5C, ATP5CL1, ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, ATP5C1, ATP synthase F1 subunit gamma
External IDs	OMIM: 108729; MGI: 1261437; HomoloGene: 3792; GeneCards: ATP5F1C; OMA:ATP5F1C - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p14 Start 7,788,147 bp[1] End 7,807,815 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 10,060,827 bp[2] End 10,085,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle myocardium of left ventricle vena cava triceps brachii muscle body of tongue biceps brachii deltoid muscle right adrenal gland right adrenal cortex glutes Top expressed in myocardium of ventricle cardiac muscles thoracic diaphragm extraocular muscle masseter muscle plantaris muscle triceps surae interventricular septum quadriceps femoris muscle extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton-transporting ATP synthase activity, rotational mechanism transmembrane transporter activity ATPase activity RNA binding proton-transporting ATPase activity, rotational mechanism Cellular component mitochondrial proton-transporting ATP synthase complex membrane myelin sheath mitochondrial matrix mitochondrion mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) mitochondrial inner membrane proton-transporting ATP synthase complex, catalytic core F(1) extracellular exosome Biological process mitochondrial ATP synthesis coupled proton transport ion transport oxidative phosphorylation ATP synthesis coupled proton transport ATP biosynthetic process cristae formation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 509 11949 Ensembl ENSG00000165629 ENSMUSG00000025781 UniProt P36542 Q91VR2 RefSeq (mRNA) NM_001001973 NM_005174 NM_001320886 NM_001112738 NM_020615 NM_001374641 RefSeq (protein) NP_001001973 NP_001307815 NP_005165 NP_001106209 NP_065640 NP_001361570 Location (UCSC) Chr 10: 7.79 – 7.81 Mb Chr 2: 10.06 – 10.09 Mb PubMed search [3] [4]
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This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes adenosine triphosphate (ATP) synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F₀, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.^[7]