CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.^[5][6] It is also called CD166 (cluster of differentiation 166), MEMD,^[7] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat.

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ALCAM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A2F
Identifiers
Aliases	ALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule
External IDs	OMIM: 601662; MGI: 1313266; HomoloGene: 1229; GeneCards: ALCAM; OMA:ALCAM - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.11 Start 105,366,909 bp[1] End 105,576,900 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 52,069,359 bp[2] End 52,274,437 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell endothelial cell palpebral conjunctiva corpus callosum visceral pleura external globus pallidus trigeminal ganglion inferior ganglion of vagus nerve lower lobe of lung superior vestibular nucleus Top expressed in olfactory tubercle vas deferens right lung lobe left lung lobe stria vascularis nucleus accumbens globus pallidus ventromedial nucleus renal corpuscle mammillary body More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding signaling receptor binding identical protein binding Cellular component integral component of membrane cell projection membrane focal adhesion intrinsic component of plasma membrane plasma membrane integral component of plasma membrane T cell receptor complex extracellular region axon neuronal cell body dendrite immunological synapse extracellular exosome external side of plasma membrane Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules adaptive immune response immune system process neuron projection extension cell adhesion motor neuron axon guidance axon extension involved in axon guidance signal transduction retinal ganglion cell axon guidance axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 214 11658 Ensembl ENSG00000170017 ENSMUSG00000022636 UniProt Q13740 Q61490 RefSeq (mRNA) NM_001627 NM_001243280 NM_001243281 NM_001243283 NM_009655 NM_001331110 RefSeq (protein) NP_001230209 NP_001230210 NP_001230212 NP_001618 NP_001318039 NP_033785 Location (UCSC) Chr 3: 105.37 – 105.58 Mb Chr 16: 52.07 – 52.27 Mb PubMed search [3] [4]
Wikidata
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Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands.^{[citation needed]} CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma.^[7] CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.^{[citation needed]}

Recently, CD166 has also been used as a potential cancer stem cell marker.^{[citation needed]}