AKAP7

AKAP7

AKAP7

Protein-coding gene in the species Homo sapiens

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.[5][6]

Quick Facts Available structures, PDB ...

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.[6]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000118507 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000039166 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
  6. [6]
    "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

Further reading


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