ADAM_17_endopeptidase

ADAM 17 endopeptidase

ADAM 17 endopeptidase

Class of enzymes

ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Quick Facts Identifiers, EC no. ...

This enzyme belongs to the peptidase family M12.

References

  1. [1]
    Black RA (January 2002). "Tumor necrosis factor-alpha converting enzyme". The International Journal of Biochemistry & Cell Biology. 34 (1): 1–5. doi:10.1016/S1357-2725(01)00097-8. PMID 11733179.
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