ACER3

ACER3
Identifiers
Aliases	ACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO
External IDs	OMIM: 617036; MGI: 1913440; HomoloGene: 5410; GeneCards: ACER3; OMA:ACER3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,026,797 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,321,208 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; inferior ganglion of vagus nerve; ; mucosa of ileum; ; corpus callosum; ; pancreatic epithelial cell; ; pars reticulata; ; Pars compacta; ; Brodmann area 46; ; subthalamic nucleus; ; buccal mucosa cell;
	Top expressed in
	conjunctival fornix; ; cornea; ; interventricular septum; ; hair follicle; ; sciatic nerve; ; skin of back; ; skin of abdomen; ; epithelium of stomach; ; right lung; ; otolith organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; phytoceramidase activity; N-acylsphingosine amidohydrolase activity; dihydroceramidase activity; ceramidase activity; calcium ion binding; zinc ion binding; metal ion binding;
Cellular component	integral component of membrane; integral component of Golgi membrane; integral component of endoplasmic reticulum membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	sphingosine biosynthetic process; sphingolipid biosynthetic process; phytosphingosine biosynthetic process; ceramide metabolic process; positive regulation of cell population proliferation; inflammatory response; myelination; regulation of programmed cell death; ceramide catabolic process; lipid metabolism; sphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	55331
	66190
	ENSG00000078124
	ENSMUSG00000030760
	Q9NUN7
	Q9D099
	NM_001300953; NM_001300954; NM_001300955; NM_018367
	NM_025408
	NP_001287882; NP_001287883; NP_001287884; NP_060837
	NP_079684; NP_001347544; NP_001347545; NP_001347546
	Wikidata
View/Edit Human	View/Edit Mouse

ACER3

Protein-coding gene in the species Homo sapiens

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.^[5]^[6]

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This article uses material from the Wikipedia article ACER3, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000078124 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000030760 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11356846-5] [5]
Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM (July 2001). "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. Chem. 276 (28): 26577–88. doi:10.1074/jbc.M102818200. PMID 11356846.

[pmid18619555-6] [6]
Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.

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ACER3

ACER3

References

External links

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