ACER1

ACER1
Identifiers
Aliases	ACER1, ALKCDase1, ASAH3, alkaline ceramidase 1
External IDs	OMIM: 613491; MGI: 2181962; HomoloGene: 15853; GeneCards: ACER1; OMA:ACER1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,333,612 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,289,126 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; skin of thigh; ; vulva; ; human penis; ; nipple; ; oral cavity; ; vagina; ; lymph node; ; ectocervix;
	Top expressed in
	lip; ; condyle; ; skin of back; ; epithelium of stomach; ; left colon; ; epidermis; ; skin of abdomen; ; Paneth cell; ; hair follicle; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	dihydroceramidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; N-acylsphingosine amidohydrolase activity; ceramidase activity; metal ion binding;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	cellular response to calcium ion; regulation of lipid metabolic process; cell differentiation; sphingosine biosynthetic process; sphingolipid biosynthetic process; response to alkaline pH; keratinocyte differentiation; ceramide metabolic process; epidermis development; lipid metabolism; ceramide catabolic process; sphingolipid metabolic process; regulation of water loss via skin; sebaceous gland development;
	Sources:Amigo / QuickGO
Orthologs
	125981
	171168
	ENSG00000167769
	ENSMUSG00000045019
	Q8TDN7
	Q8R4X1
	NM_133492
	NM_175731
	NP_597999
	NP_783858
	Wikidata
View/Edit Human	View/Edit Mouse

ACER1

Protein-coding gene in the species Homo sapiens

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.^[5]

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This article uses material from the Wikipedia article ACER1, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000167769 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000045019 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12783875-5] [5]
Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM (Aug 2003). "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides". The Journal of Biological Chemistry. 278 (33): 31184–91. doi:10.1074/jbc.M303875200. PMID 12783875.

[5]

[1]

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[3]

[4]

ACER1

ACER1

Function

References

External links

Further reading

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