ACBD3

ACBD3

ACBD3

Protein-coding gene in the species Homo sapiens

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.[5]

Quick Facts Available structures, PDB ...

Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.[6] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.[5]

Interactions

ACBD3 has been shown to interact with GOLGB1.[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000182827 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000026499 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
  6. [6]
    "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".
  7. [7]
    Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.

Further reading

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