The 2021 Pocono Organics CBD 325 was a NASCAR Cup Series race that was held on June 26, 2021, at Pocono Raceway in Long Pond, Pennsylvania. Contested over 130 laps on the 2.5-mile (4.0 km) triangular racecourse, it was the 18th race of the 2021 NASCAR Cup Series season.

• (R) denotes rookie driver.
• (i) denotes driver who are ineligible for series driver points.

Kyle Larson was awarded the pole for the race as determined by competition-based formula.^[4]

For pre-race ceremonies, Monty Self of Motor Racing Outreach gave out the invocation. Ellen Kane would sing the national anthem. A singular USAF C-17 Globemaster III would perform a flyover at the end of the national anthem. Jeff Moyer, CEO of Rodale Institute, would give the starting command.

Kyle Larson would lead the first 5 laps before being passed by William Byron on lap 6. On lap 10, a caution was called for debris in Turn 2. On the restart, Byron would pull away but a lap later, Brad Keselowski, in an attempt to go under Cole Custer, hit Custer in the back and sent Custer into the outside wall, sending cars scattering as Custer slid down into the inside wall. Custer would retire from the race. After pit stops, Kyle Busch would assume the lead. Kyle Busch would pull away from William Byron on the restart and go on to win Stage 1.

On the final lap, Larson would blow a tire on the final turn, hitting the Turn 3 wall. Bowman, who was second at the time would pass Larson and win the race. Larson would eventually crawl to the line, finishing ninth.