The 2021 NASCAR Cup Series Championship Race was a NASCAR Cup Series race held on November 7, 2021 at Phoenix Raceway in Avondale, Arizona. Contested over 312 laps on the one mile (1.6 km) oval, it was the 36th and final race of the 2021 NASCAR Cup Series season, and was also the last race for the Generation 6 car body, as it was replaced in 2022 by the Next Gen Car. Kyle Larson won the race and claimed his first NASCAR Cup Series Championship.

Brad Keselowski was the fastest in the practice session with a time of 26.591 with an average speed of 135.384 mph (217.879 km/h).^[10]

Kyle Larson scored the pole for the race with a time of 26.116 and a speed of 137.847 mph (221.843 km/h).^[11]

• Note: Kyle Larson, Martin Truex Jr., Denny Hamlin, and Chase Elliott are not eligible for stage points because of their participation in the Championship 4.

Kyle Larson won the pole position for the race. The majority of the race saw the Championship 4 drivers in the front, with Martin Truex Jr. winning Stage 1 and Larson winning Stage 2. With 60 laps to go, Truex made a pit stop as rookie Anthony Alfredo wrecked, but Truex was able to exit pit road on the lead lap before the caution came out. Truex took the lead when the other Championship 4 drivers pitted during caution. Truex was leading the race with 30 laps to go when the caution came out for the wrecked David Starr. In the final pit stop of the season, Hamlin's pit crew conducted a 12.1 second pit stop that would have allowed Hamlin to exit pit road with the lead. But with Larson in the first pit stall and Larson's pit crew conducting an 11.8 second pit stop (the second fastest time for the crew in the season), Larson was able to exit pit road with the lead. When green flag racing resumed with 24 laps to go, Larson got a good jump to clear the other drivers, but Truex was able to follow close behind. Despite some close challenges from Truex in the final laps, Larson held on to win his tenth race of the season and his first career NASCAR Cup Championship. Truex Jr., Hamlin and Elliott would finish 2nd, 3rd and 5th respectively in the race to finish in the point standings 2nd, 3rd and 4th respectively.