The 2015–16 Philadelphia 76ers season, the team's 77th in the National Basketball Association (NBA), was the second worst in franchise history, one game better than their 9–73 mark in the 1972–73 season.^[1] It was also the second straight season that Joel Embiid, the third pick in the 2014 NBA draft, would not suit up for the 76ers due to a leg injury. Philadelphia broke the record for the longest losing streak in American professional sports history with 27 straight losses over this season and last season with a 114–116 loss to the Houston Rockets (the old record of 26 was held by the 2010-11 Cleveland Cavaliers). The losing streak would reach to 28 games (with the 18 straight losses tying the record for longest opening season losing streak with the 2009–10 New Jersey Nets) before getting their first victory at home against the Los Angeles Lakers, which was also Kobe Bryant's last game against the 76ers in Philadelphia. Philadelphia would also hire former Phoenix Suns owner, coach, general manager, and four-time NBA Executive of the Year winner Jerry Colangelo on December 7, 2015, as their Chairman of Basketball Operations. Eleven days later, former Denver Nuggets, Phoenix Suns, New York Knicks, and Los Angeles Lakers head coach Mike D'Antoni would join the team as an associate head coach. Near the end of the season, general manager Sam Hinkie would announce his resignation from his position, being replaced by Jerry's son Bryan Colangelo before the end of the season. Jerry would also announce his personal demotion from his original position afterwards.

The 76ers finished just one game shy of tying the NBA record for most losses in a season, set by the Sixers themselves during their 1972–73 season when they went 9–73. They became only the second team after the Vancouver Grizzlies between 1995–96 and 1997–98 to endure three consecutive 82-game seasons with fewer than twenty wins. However, it would be the season where Sam Hinkie's goal of "The Process" came into full fruition since they'd later earn the #1 selection in the 2016 NBA draft, which became Ben Simmons.

• • Denotes home game sellout.

The following are some awards that took place during the 2015 season for Sixers players.

• Eastern Conference Rookie of the Month (Jahlil Okafor) December
• Eastern Conference Rookie of the Month (T. J. McConnell) February
• NBA All-Rookie First Team (Jahlil Okafor)