#18 Baker at #11 Ottawa

Baker and Ottawa met in the season's first NAIA "Game of the Week" on August 25. This was the sixth time that both teams have met in their season opener, and the 81st meeting all-time for the two programs. Going into the game, Baker led the rivalry 45-33-2 including a 41-16 victory in 2011.^[8]

Ottawa came to the game winning the conference two of the last three seasons and with three consecutive post-season appearances. Baker has five consecutive winning seasons and five rankings in the top 25 final poll.^[9] Baker plays in the Heart of America Athletic Conference, considered one of the strongest in the NAIA.^[10]

When the game got under way, Baker scored first with a 12-yard field goal by Steven Stewart with 8:13 left in the first quarter, but not after losing starting quarterback Jake Morse to injury for the remainder of the game. With 4:45 left in the first, Ottawa answered back with a touchdown and kicked the extra point to make the score 7–3. One more field goal by each team put the score 10–6 at halftime.^[11]

In the fourth quarter, Baker took the score from tied up at 13–13 to a 27–13 lead by capitalizing on two turnovers. With 1:49 left to play, Ryder Werts fell on the ball in the end zone for a touchdown and kicker Steven Stewart made the extra point to put the Wildcats up by seven. Just 29 seconds later, Baker's Emmerson Clarke took a 48-yard interception return for a touchdown. Stewart's extra point put the score at 27–13. Ottawa managed a final touchdown with five seconds to go in the fourth quarter to put the final score at 27–20, with Baker recording the upset victory over the higher-ranked team.^[11]

Baker had two key players injured during and prior to the game. Morse's injury was somewhat of a repeat of the matchup in 2010, when he left the game due to a concussion. Just one week earlier, Junior Scott Meyer’s season ended from injury in a scrimmage game against Fort Scott Community College.^[12]

Ottawa began the game without offensive starter Matt Bollig, who suffered a career-ending injury during weightlifting practice in July.^[13]

Tabor at Bacone

Tabor traveled to Muskogee, Oklahoma for their game against Bacone for the second of two games in the conference for the week. Bacone coach Trevor Rubly began the game looking for his squad to improve over last year's statistics in turnovers beginning with this game.^[14] Last year Tabor completed a 3-7 overall record and 2-7 in conference play, but was picked to finish higher in both media and coaches conference poll.^[15]

Bacone managed to get off to an early start, scoring 10 points in the first quarter and leading at halftime 13–0. Tabor showed heart in the third quarter by scoring 20 points and made a good attempt at a comeback,^[16] but allowed Bacone to tack on an additional 12 to win the game 25–20.^[17]

Southwestern at #10 Northwestern (IA)

Tenth ranked Northwestern hosted the Southwestern College Moundbuilders on a Thursday night game in front of 2,347 fans.^[19] Southwestern entered the game with optimism of a victory and breaking a losing streak.^[20]

Northwestern dominated play the entire game. Head coach Kyle Achterhoff led his team to 649 yards and 7 touchdowns, averaging 7.1 yards per play while holding Southwestern to 156 yards and no points. Southwestern's Ceth Bannister managed a 64-yard punt in the game as a bright spot for Southwestern. The final score was 49–0 with Northwestern winning.^[21]

#14 William Penn at Bethel

Bethel's interim coach James Dotson had just 41 players suited up for their season opener, against 14th-ranked William Penn. William Penn scored 29 points in the first quarter alone and dominated every aspect of the game.^[22] The Statesmen came into the game off a 39–14 victory over Iowa Wesleyan the previous week.^[23]

William Penn piled on 474 yards of total offense and seven touchdowns while holding Bethel to just 49 yards with no scores. The final score was 54–0.^[24]

Kansas Wesleyan at #22 Cumberland

Kansas Wesleyan met #22 Cumberland in the "Big River Bowl" hosted in Dyersburg, Tennessee, the first of two games played that day at the location.^[25]

Kansas Wesleyan secured 207 yards in the first half but only 45 in the second half of the game.^[22] Cumberland led 14–10 at halftime, and then began the third quarter with a 52-yard touchdown pass to Marquis Hagewood.^[26] Cumberland finished the game with 451 yards of total offense, including 317 on the ground.^[27] Cumberland claimed victory by a score of 31–10.^[28]

Sterling at #13 Benedictine

The Benedictine Ravens played host to the Sterling Warriors and dominated every aspect of the game.

The Ravens achieved 429 yards in total offense with eight touchdowns while Sterling earned just 265 and one touchdown. Sterling lost four fumbles and another interception while only making good on 3 of 14 third down situations. Benedictine lost two fumbles and zero interceptions while converting 6 of 11 third downs. The final score was Benedictine 59, Sterling 6.^[29]

Saint Mary at Nebraska Wesleyan

Saint Mary's Jerrell Young caught a 9-yard pass from Mike Keese for a touchdown in the first quarter to get off to a 7–0 lead. Wesleyan's Nate Hauptman made good on a 1-yard run for a touchdown in the second quarter to tie up the score, but Saint Mary pulled ahead when Marcus Mata ran for a four-yard touchdown and Saint Mary went in at halftime with a 14–7 lead.^[30]

Saint Mary's top-flight passing attack helped give the Spires a 458-242 edge in total offense. Quarterback Mike Keese - who threw for 3,638 yards and 21 touchdowns a year ago - was 30-of-54 for 377 yards and two touchdowns.^[22]

Saint Mary still held a thin lead when Wesleayn's Nate Hauptman threw a 30-yard pass to Ryan Larsen for a touchdown because the extra point was blocked. Saint Mary held a 14–13 lead. But two more scores by Wesleyan in the third quarter made a difference, as Aaron Lorraine made a 31-yard field goal and Dustin Bryant scored on a 7 yard carry to end the third quarter 23–14.^[30]

Nebraska Wesleyan scored on three straight possessions in the second half and batted down a fourth-and-goal pass in the end zone to hold on for the win.^[22] Saint Mary attempt to come back in the fourth quarter fell short and Nebraska Wesleyan won 25–20.^[30]

Friends at Evangel

Evangel began its season opener against Friends looking to bounce back from last season's record of 3–7, depending on their more experienced players such as pre-season second team all-American linebacker Tabor Cheo.^[31]

Evangel's Jesse Vaughn caught a 31-yard pass from Andrew Brimhal for a touchdown in the first quarter to take the lead and Evangel held the lead for the remainder of the game. Evangel's offense out-produced Friends 419 yards to 374, with three touchdowns to two by the Falcons. The final score was Friends 14, Evangel 27.^[32]

#9 Missouri Valley at McPherson

The lead changed five times when #9 Missouri Valley traveled to play McPherson. Missouri Valley achieved 377 yards of total offense and three touchdowns while McPherson nearly matched with 376 yards but only two touchdowns. McPherson was intercepted twice where Missouri Valley was not, but McPherson only committed one penalty to Missouri Valley's seven. In the end, Missouri Valley claimed victory 27–13.^[33]

#24 Bethany at Southwestern Assemblies of God

Last season Southwestern Assemblies of God (SAGU) ended with a record of 4 wins and 6 losses. The team returned 13 starting players for the new season, including quarterback Reid Golson and running backs Sean Haynes and Cade Leuschner.^[34]

Bethany's Darby House managed to throw two touchdown passes to offset SAGU's four field goals. One touchdown pass was caught by Brandon Martino and the other by teammate D'Andre Thompson. The second to Thompson came with 37 seconds left in the game.^[18] It was just enough for a 13–12 victory.^[35]

#11 Ottawa at Kansas Wesleyan

Underdog Kansas Wesleyan ended the first quarter with a 17–7 lead and held it for the remainder of the game, although 11th-ranked Ottawa did manage to work up what looked like a comeback. Ottawa's offense achieved 512 total yards and held Kansas Wesleyan to 327 and four touchdowns apiece. The difference came down to kicking, as Kansas Wesleyan's Terry Stecker managed a field goal to put the Coyotes far enough ahead to keep the victory. Final score: Kansas Wesleyan 31, Ottawa 28.^[37]

McPherson at #24 Bethany

Only two touchdowns came in the game between McPherson and Bethany in the home opener for the Terrible Sweedes, and both of those touchdowns were achieved by McPherson. The first one came with just thirteen seconds left in the second quarter when Havelock Pomele made a 2-yard run to score, and Cord Cunningham converted the extra point to put the score to 7–0. The second touchdown, also by Pomele was a 13-yard run with 14:53 left in the fourth quarter. Cunningham made good on the extra point for the second time and the result was a McPherson upset over #24 Bethany by a score of 14–0.^[38]

Avila vs. Bethany

Avila and Bethany played their game as scheduled and Avila outscored Bethany by a score of 35–19.^[39] Avila would later forfeit the victory due to the use of an ineligible player.^[40]

#22 Tabor vs. McPherson - cancelled

On October 4, 2012, the KCAC and presidents of McPherson and Tabor agreed to cancel their game scheduled for October 20, 2012.^[41] The game was cancelled in light of the ongoing investigation into the murder of Tabor football player Brandon Brown. The two suspected of committing the murder are former football players from McPherson College.^[42]

#15 Ottawa (KS) at #2 Missouri Valley

Missouri Valley finished the regular season with its third consecutive conference championship and an undefeated 10–0 record, while Ottawa entered into the game with its second consecutive conference championship and a record of 8–2.^[53] Missouri Valley earned the home field advantage for the first round.^[54]

Missouri Valley scored 15 points in the first quarter and held Ottawa to zero, and held that lead for the entire game. Missouri Valley averaged 6.9 yards per play while holding Ottawa to 2.7. Missouri Valley's 487 total yards was made up of 229 yards rushing and 258 passing. With 13:46 left in the second quarter, Ottawa scored and managed to bring the score within eight points, but Missouri Valley pulled further away to a victorious final score of 56–21.^[55]