September

• September 11 – In the first conference game of the season, #25 Stanford defeated UCLA in a 35–0 shut out at the Rose Bowl, marking several firsts: the Cardinal's first victory in Pasadena since 1996, the first home shut out UCLA had suffered since an October 16, 1999, 17–0 loss to California, the first time Stanford had shut out an opponent on the road since 1974, and the first time since 1941 that Stanford shut out UCLA.
• September 17 – In a matchup between the number one defense in the nation in Cal and the number one offense in the nation in Nevada, the Bears fell to the Wolf Pack 52–31 in Reno in the teams' first meeting since 1915.
• September 18 – Oregon records two shutouts in a season for the first time since 1964 with a 69–0 blowout of Portland State and a 72–0 shut out of New Mexico in its September 4 season opener.^[9] Two Pac-10 teams upset their opponents: UCLA defeated No. 23 Houston in the Rose Bowl for the Bruins' first win against a ranked opponent since 2008^[10] and Arizona defeated No. 10 Iowa at home, scoring the most points allowed so far by the Hawkeyes in the season.^[11]
• September 19 – Five Pac-10 teams are ranked in the Top 25 (#5 Oregon, #14 Arizona, #16 Stanford, #20 USC, #24 Oregon State).
• September 21 – Colorado and the Big 12 Conference reach an agreement that will allow the Buffaloes to join the Pac-10 in 2011.^[4]
• September 25 – UCLA pulls off its second upset in a row of a ranked opponent with a 34–12 defeat of No. 7 Texas in front of a stadium-record crowd of 101,437 in Austin. Stanford wins at Notre Dame for the first time since 1992.^[12] No. 14 Arizona survives a scare in Tucson with a late touchdown and interception against Cal to hold on and prevent an upset in both teams' Pac-10 openers. Four Pac-10 teams (#4 Oregon, #9 Stanford, #14 Arizona, #18 USC) are 4–0.

October

• October 2 – #9 Stanford visited #4 Oregon in a game that could decide the Pac-10 championship in their first meeting as ranked teams.^[13] The Ducks rallied to come from behind 21–3 and defeat the Cardinal. Washington upset #18 USC for two consecutive years, winning at the Los Angeles Memorial Coliseum 32–31 with a last-second field goal.
• October 9 – #3 Oregon remains the sole undefeated Pac-10 team at 6–0 with a victory over Washington State. Oregon State upsets #9 Arizona 29–27 in Tucson. Cal snaps a 3-game winning streak by UCLA with a 35–7 rout in Berkeley. #16 Stanford defeats USC 37–35 for the Trojans' second loss in a row on a last-second field goal.
• October 16 – USC quarterback Matt Barkley throws a school record-tying five touchdowns in a 48–14 blowout victory over Cal. Cal has won three games (all at home) by the margin of 139–17 and lost three games (all on the road) 110–54. Washington upsets #24 Oregon State in 35–34 in double overtime, snapping a six-game losing streak to the Beavers. Both teams were tied at 21 points apiece at the end of regulation.
• October 17 – Oregon earns a #1 ranking in the AP and Coaches' Polls and a #2 BCS ranking.
• October 21 – Oregon quarterback Darron Thomas throws for a career-high 308 yards in a 60–13 blowout of UCLA.
• October 23 – Stanford gets their sixth victory in seven games to open a season for the first time since 1970 with a victory over Washington State, becoming bowl-eligible for the second straight season since 1995–96.^[14] Cal defeats Arizona State 50–17, while #15 Arizona routs Washington 44–14.

• October 30 – Arizona State shuts out Washington State 42–0 and Washington is shut out at home for the first time since 1976 by No. 13 Stanford 41–0.^[15] No. 15 Arizona holds off UCLA to prevail 29–21, while Oregon State defeats Cal for the fourth time in a row, 35–7. Oregon running back LaMichael James sets a school record with his 15th career 100-yard rushing game and Darron Thomas becomes the first quarterback to throw 20 touchdown passes in a season since 2007 as #1 Oregon stays unbeaten with a 53–32 defeat of #24 USC.^[16]

• October 31 – Oregon is ranked first in the BCS, AP, and Coaches Polls.

November

• November 6 – Top-ranked Oregon fails to score in the first quarter for the first time in the season in a 53–16 rout of Washington. #10 Stanford dominates #13 Arizona in a 42–17 victory. USC edges out Arizona State 34–33 after a last minute Sun Devils field goal misses. UCLA defeats Oregon State 17–14 on a field goal with 1 second left in regulation. Cal holds off Washington State for its first road victory since the 2009 Big Game against Stanford.
• November 13 – Oregon is held scoreless in the first quarter for the second week in a row and held to a season-low 317 yards of offense, but holds off Cal for a 15–13 victory, the first game of the season where the Ducks did not score at least 42 points and win by at least 11 points. #7 Stanford edges out Arizona State 17–13. USC upsets #18 Arizona 24–21. Washington State snaps a 16-game conference losing streak by defeating Oregon State 31–14 in Corvallis.
• November 14 – Oregon holds its #1 rankings in all polls. Stanford holds its #7 ranking in the AP Poll and its #8 ranking in the Harris Polls while rising from #9 to #8 in the Coaches Poll. Arizona falls to #23 in all polls. USC returns to the AP rankings at #20. Three Pac-10 teams are bowl assured: Oregon, Stanford, and Arizona.
• November 18 – In its home finale, Washington has two 100-yard rushers for the first time since 2007 and puts up a season-high 253 yards rushing in a 24–7 defeat of UCLA.
• November 20 – #7 Stanford ties a 1975 Cal record for the most points in Big Game history to recapture the Stanford Axe from Cal in Berkeley, 48–14. Oregon State upsets #20 USC at Corvallis 36–7, the third consecutive victory for the Beavers over the Trojans in Oregon. They will have faced five Top 10 teams by the end of the year.
• November 26 – Arizona State tops UCLA 55–34. Wildcats quarterback Nick Foles passes for a career-high 448 yards, but his performance is not enough to stage an upset of #1 Oregon by #20 Arizona, as the Ducks prevail 48–29.
• November 27 – Washington keeps its bowl hopes alive by scoring a touchdown with 2 seconds left in the game in a matchup against Cal to prevail 16–13, ending Cal's bowl hopes. #6 Stanford has its first 11-game winning season in school history with a 38–0 shutout of Oregon State, its third conference shutout of the season. Notre Dame defeats USC 20–16 for its first win since 2001. Oregon moves down in the BCS rankings to #2, while Stanford moves up to #4.

December

• December 2 – Arizona State blocks two PATs to defeat Arizona in double overtime 30–29 in their annual Territorial Cup game.
• December 3 – The NCAA denies Arizona State's request for a waiver to play in a post-season bowl game.^[17]
• December 4 – Oregon repeats as the conference champion with a victory over Oregon State in the Civil War to finish with 12 wins for the first time in program history. USC defeats UCLA for the fourth straight time to hold on to the Victory Bell. Washington defeats Washington State in the Apple Cup on a game-winning touchdown with 44 seconds left in the game to become bowl-eligible for the first time since 2001.
• December 5 – Auburn moves past Oregon for the #1 AP Ranking. The two teams will meet in the BCS National Championship Game. #5 Stanford won an at-large BCS berth and will face ACC Champion Virginia Tech in the Orange Bowl, Arizona will face #16 Oklahoma State in the Alamo Bowl, and Washington will face #17 Nebraska in the Holiday Bowl.
• December 6 – Two of the four finalists for the Heisman Trophy represent the Pac-10: Oregon running back LaMichael James and Stanford quarterback Andrew Luck. This is the second year in a row that Stanford has had a Heisman Trophy finalist. Oregon head coach Chip Kelly is named the Eddie Robinson Coach of the Year by the Football Writers Association of America.
• December 9 – Oregon running back LaMichael James is the recipient of the Doak Walker Award, the second year in a row that a Pac-10 running back has received the award.
• December 11 – Stanford quarterback Andrew Luck is the runner-up in Heisman Trophy balloting to Auburn quarterback Cameron Newton, the second year in a row that a Stanford player is the runner-up in balloting for the Heisman.
• December 21 – Oregon head coach Chip Kelly is named the Associated Press College Football Coach of the Year. Stanford's Jim Harbaugh finished third in balloting.

All-Americans

Walter Camp Football Foundation All-America:^[40]

• Running back LaMichael James, Oregon, first team All-America
• Quarterback Andrew Luck, Stanford, second team All-America
• Center Chase Beeler, Stanford, second team All-America
• Linebacker Akeem Ayers, UCLA, second-team All-America
• Defensive back Cliff Harris, Oregon, second-team All-America
• Kick returner Cliff Harris, Oregon, second-team All-America

Associated Press All-America First Team:

• RB LaMichael James, Oregon
• OL Chase Beeler, Stanford
• DT Stephen Paea, Oregon State

FWAA All-America Team:

Sporting News All-America team:^[41]

• RB LaMichael James, Soph., Oregon, Offense first-team
• OL Chase Beeler, Sr., Stanford, Offense first-team
• DT Stephen Paea, Sr., Oregon State, Defense first-team
• LB Vontaze Burfict, Soph., Arizona State, Defense first-team
• S Rahim Moore, Jr., UCLA, Defense first-team
• PR Cliff Harris, Soph., Oregon, Defense first-team

AFCA Coaches' All-Americans First Team:

ESPN All-America team:

All-Pac-10 teams

• Offensive Player of the Year: Andrew Luck, QB, Stanford
• Pat Tillman Defensive Player of the Year: Stephen Paea, DT, Oregon State
• Offensive Freshman of the Year: Robert Woods, WR, USC
• Defensive Freshman of the Year: Junior Onyeali, DE, Arizona State
• Coach of the Year: Chip Kelly, Oregon

First Team:

ST=special teams player (not a kicker or returner)

All-Academic

First Team:^[42]