The 2000 Indiana Hoosiers football team represented Indiana University Bloomington during the 2000 NCAA Division I-A football season. They participated as members of the Big Ten Conference. The Hoosiers played their home games at Memorial Stadium in Bloomington, Indiana. The team was coached by Cam Cameron in his fourth year as head coach.

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Date	Time	Opponent	Site	TV	Result	Attendance
September 9	12:00 pm	NC State*	Memorial Stadium Bloomington, IN	ESPN2	L 38–41	30,151
September 16	6:00 pm	at Kentucky*	Commonwealth Stadium Lexington, KY (rivalry)	ESPN2	L 34–41	70,776
September 23	1:00 pm	Cincinnati*	Memorial Stadium Bloomington, IN		W 42–6	30,075
September 30	12:00 pm	Iowa	Memorial Stadium Bloomington, IN	ESPN Plus	W 45–33	31,225
October 7	12:00 pm	at No. 22 Northwestern	Ryan Field Evanston, IL	ESPN Plus	L 33–52	30,201
October 14	3:30 pm	at No. 18 Michigan	Michigan Stadium Ann Arbor, MI	ABC	L 0–58	110,909
October 21	1:00 pm	No. 22 Minnesota	Memorial Stadium Bloomington, IN		W 51–43	30,882
October 28	7:00 pm	vs Penn State	RCA Dome Indianapolis, IN	ESPN2	L 24–27	43,122
November 4	12:00 pm	at Illinois	Memorial Stadium Champaign, IL	ESPN+	L 35–42	54,283
November 11	12:00 pm	Wisconsin	Memorial Stadium Bloomington, IN	ESPN+	L 22–43	30,469
November 18	3:30 pm	at No. 17 Purdue	Ross–Ade Stadium West Lafayette, IN (Old Oaken Bucket)	ABC	L 13–41	69,104
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Eastern time

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