2-hydroxyphytanoyl-CoA_lyase

2-hydroxyphytanoyl-CoA lyase

2-hydroxyphytanoyl-CoA lyase

Class of enzymes

2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor.[1]

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It is classified under EC number 4.1.

References

  1. [1]
    Foulon V, Antonenkov V, Croes K, et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039–44. Bibcode:1999PNAS...9610039F. doi:10.1073/pnas.96.18.10039. PMC 17838. PMID 10468558.
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