The 1980 Vanderbilt Commodores football team represented Vanderbilt University in the 1980 NCAA Division I-A football season. The Commodores were led by head coach George MacIntyre in his second season and finished the season with a record of two wins and nine losses (2–9 overall, 0–6 in the SEC).

More information Date, Opponent ...

Date	Opponent	Site	Result	Attendance	Source
September 13	at Maryland*	Byrd Stadium College Park, MD	L 6–31	27,150	[1]
September 20	Mississippi State	Dudley Field Nashville, TN	L 14–24	29,300	[2]
September 27	at No. 1 Alabama	Bryant–Denny Stadium Tuscaloosa, AL	L 0–41	60,210	[3]
October 11	Tulane*	Dudley Field Nashville, TN	L 21–43	35,960	[4]
October 18	at No. 6 Georgia	Sanford Stadium Athens, GA (rivalry)	L 0–41	59,300	[5]
October 25	Ole Miss	Dudley Field Nashville, TN (rivalry)	L 14–27	27,800	[6]
November 1	at Memphis State*	Liberty Bowl Memorial Stadium Memphis, TN	W 14–10	18,422	[7]
November 8	at Kentucky	Commonwealth Stadium Lexington, KY (rivalry)	L 10–31	54,522	[8]
November 15	Miami (FL)*	Dudley Field Nashville, TN	L 17–24	12,830	[9]
November 22	Chattanooga*	Dudley Field Nashville, TN	W 31–29	22,700	[10]
November 29	Tennessee	Dudley Field Nashville, TN (rivalry)	L 13–51	31,100	[11]
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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