The 1946 Purdue Boilermakers football team was an American football team that represented Purdue University during the 1946 Big Ten Conference football season. In their third season under head coach Cecil Isbell, the Boilermakers compiled a 2–6–1 record, finished in last place in the Big Ten Conference with an 0–5–1 record against conference opponents, and were outscored by their opponents by a total of 208 to 97.^[1][2]

Notable players from the 1946 Purdue team included quarterback Bob DeMoss, guard Dick Barwegen, and back Bulbs Ehlers. DeMoss ranked ninth nationally with 59 pass completions, good for 814 yards.^[3]

Purdue was ranked at No. 48 in the final Litkenhous Difference by Score System rankings for 1946.^[4]

More information Date, Opponent ...

Date	Opponent	Site	Result	Attendance	Source
September 21	Miami (OH)*	Ross–Ade Stadium West Lafayette, IN	W 13–7	23,000	[5]
September 28	at Iowa	Iowa Stadium Iowa City, IA	L 0–16	36,000	[6]
October 5	at Illinois	Memorial Stadium Champaign, IL (rivalry)	L 7–43	38,519	[7]
October 12	at No. 3 Notre Dame*	Notre Dame Stadium Notre Dame, IN (rivalry)	L 6–49	55,452	[8]
October 19	at Ohio State	Ohio Stadium Columbus, OH	T 14–14	76,025	[9]
October 26	at Pittsburgh*	Pitt Stadium Pittsburgh, PA	W 10–8	38,000	[10]
November 2	No. 18 Wisconsin	Ross–Ade Stadium West Lafayette, IN	L 20–24	32,000	[11]
November 9	at Minnesota	Memorial Stadium Minneapolis, MN	L 7–13	58,341	[12]
November 23	Indiana	Ross–Ade Stadium West Lafayette, IN (Old Oaken Bucket)	L 20–34	43,000	[13]
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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The 1947 NFL Draft was held on December 16, 1946. The following Boilermakers were selected.^[15]