Nebraska Wesleyan

Nebraska Wesleyan arrived in Lincoln as Nebraska's tune up game, and nearly every player on the roster found time in the game as the Cornhuskers rolled to an easy shutout victory, as Nebraska's goal was never threatened. This was the last game between these teams, ending the 5th-oldest active series in Nebraska's history to that date, all eight games Nebraska victories dating back to 1896. ^[3][7]

Haskell

For the second game in a row, Nebraska brought to a close a historic series. Nebraska's run of games with Haskell was the 7th oldest active series, dating to 1901. Much like the previous game, Nebraska was never seriously threatened and posted another shutout win, bringing the Haskell series to a close with a 7–2 record. ^[7][8]

Notre Dame

Nebraska's first ever trip to South Bend, after six straight games against Notre Dame in Lincoln, continued what had become one of the marquee games of the west. The game was all about Nebraska's stingy defense and inept offense. Time after time, the Cornhuskers turned away serious goal line threats, while also failing to find the scoreboard due to fumbles, incompletions and interceptions. Knute Rockne changed his plan for the second half, to ensure Nebraska remained scoreless and banking on eventually finding points with low-risk plays, much like the previous year's game. Chet A. Wynne was among the Notre Dame players who contributed to their one successful scoring drive, and with those points the game was decided. Nebraska fell further behind in the series, to 2-4-1. ^[7][8][9]

Oklahoma

The Cornhuskers bounced right back from the bitter loss in South Bend by blanking the reigning conference champion Oklahoma Sooners in Lincoln, in Nebraska's first conference game since returning to the league. The win moved the Cornhuskers to 2-0-1 against Oklahoma to date.

^[7][8]

Pittsburgh

Nebraska traveled to Pennsylvania for their first ever contest with Pittsburgh, known in the east as a strong team to be feared. The Cornhuskers were undaunted, taking a halftime lead and ultimately holding the Panthers scoreless for the entire game. Building on the exposure started by the 1920 victory over Rutgers the previous year, Nebraska solidified their reputation as a western powerhouse to the football fans of the east. ^[7][8]

Kansas

The Cornhuskers easily handled the Jayhawks at the homecoming game, never seriously threatened during the course of the game as Nebraska recorded their fifth shutout over their previous six games, and improved over Kansas 18-9-1 all time. ^[7][8]

Iowa State

Iowa State fired the first shot of the game, putting up an early field goal to take a 3–0 lead, but that was last time the Cyclones would speak. The Cornhuskers ruined Iowa State's homecoming game by rolling up 35 unanswered points, finishing conference play unbeaten, and improving their dominating lead over Iowa State 13-4-1. ^[7][8]

Colorado Agricultural

Nebraska finished the 1921 season with force, flattening the Colorado Agricultural football squad, 70–7. Team captain Clarence Swanson had three touchdown receptions in the game, establishing a school record that was not matched until 1971.^[10] Though the Aggies managed a 4th quarter score, Nebraska's 70 points were the most they had scored against any opponent since their 100–0 victory over Nebraska Wesleyan in 1917. Colorado Agricultural was now down 0–2 against Nebraska in games played to date. ^[7][11]