The 1906 College Football All-Southern Team consists of American football players selected to the College Football All-Southern Teams selected by various organizations for the 1906 Southern Intercollegiate Athletic Association football season. For some, the SIAA champion 1906 Vanderbilt Commodores football team made up the entire team.^[1] It would produce eight of the composite eleven. Owsley Manier was selected by Walter Camp third-team All-American. Vanderbilt won the SIAA championship.

The All-Southern eleven representing the consensus of newspapers as published in Fuzzy Woodruff's A History of Southern Football 1890-1928 included:

• Bob Blake, end for Vanderbilt, unanimous selection, was a lawyer and Rhodes Scholar.^[2] Blake made the drop kick to beat Carlisle, "the crowning feat of the Southern Intercollegiate Athletic Association season."^[3][4] He was selected for the Associated Press Southeast Area All-Time football team 1869-1919 era.^[5]
• Dan Blake, halfback for Vanderbilt, unanimous selection, brother of Bob. He later coached.
• Lob Brown, end for Georgia Tech, captain-elect who helped Tech to its first defeat over Auburn.^[6]
• Walter K. Chorn, guard for Vanderbilt, was a lawyer and one time insurance superintendent of Missouri.^[7]
• Clyde R. Conner, guard for Mississippi, was a prominent lawyer of Hattiesburg, Mississippi, and once United States Commissioner.^[8]
• Sam Costen, quarterback for Vanderbilt who once coached The Citadel Bulldogs. He was also an attorney.^[9]
• Honus Craig, halfback for Vanderbilt, Dan McGugin once called him the South's greatest athlete and Vanderbilt's greatest halfback.^[4] One report says "When Craig was confronted with the above formidable title yesterday by a reporter whose business it is to know such things, he blushed like a girl and tried to show why Dan McGugin's judgment is not always to be trusted."^[4] In Craig's opinion, Bob Blake was the South's greatest player.^[4]
• Owsley Manier, fullback for Vanderbilt, unanimous selection, a "great plunging back,"^[2] selected third-team All-America by Walter Camp. Manier scored five touchdowns against Alabama in a 78-0 victory and again ran for five touchdowns over Georgia Tech (37-6) in Atlanta.^[10] Manier was later an assistant coach and practicing physician.
• Joe Pritchard, tackle for Vanderbilt, unanimous selection, coached one year at LSU and was a Presbyterian dental missionary at Luebo in the Congo.^[11]
• Lex Stone, tackle for Sewanee, coached football and basketball at the University of Tennessee. He was the school's first basketball coach.
• Stein Stone, center for Vanderbilt, an all-time great at Vanderbilt who coached football one year at Clemson. He was an engineer.

Bold = Consensus selection

† = Unanimous selection

C = selected by consensus of newspapers, as published in Fuzzy Woodruff's A History of Southern Football 1890-1928.^[12]

AWL = selected by A. W. Lynn, sporting editor for the Atlanta Constitution.^[13]

WP = selected by The Washington Post.^[14]

MT = selected by the Macon Telegraph^[15]

MCA = selected by former Tennessee player Nash Buckingham in the Memphis Commercial Appeal.^[16][17]

PW = selected by Percy Whiting of Illustrated Outdoor News.^[3]

DM = selected by Dan McGugin head coach at Vanderbilt University, with information from Bradley Walker, southern official.^[3]

F = selected by Jack Forsythe for a game in Savannah on Christmas.^[18]

• 1906 College Football All-America Team