Zinc_transporter

Zinc transporter protein

Zinc transporter protein

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Zinc transporter proteins (Zrt), or simply zinc transporters, are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations.[1] They include two major groups: (1) the zinc transporter (ZnT) or solute carrier 30 (SLC30) family, which controls the efflux of zinc from the cytoplasm out of the cell and from the cytoplasm into vesicles; and (2) the zinc importer, Zrt- and Irt-like protein (ZIP), or solute carrier 39A (SLC39A) family, which controls the influx of zinc into the cytoplasm from outside the cell and from vesicles.[1]

At least one zinc transporter, ZIP9, is also a G protein-coupled receptor and membrane androgen receptor.[2]

Families

ZnT (SLC30)

Quick Facts Cation efflux (diffusion facilitator) protein, Identifiers ...

Members: ZnT1, ZnT2, ZnT3, ZnT4, ZnT5, ZnT6, ZnT7, ZnT8, ZnT9, ZnT10

Bacterial members of the family are known to increase tolerance to high salt concentrations.

ZntB Zinc Transporter Protein

Unlike some other zinc transporter proteins, the mechanism of how Zn2+ is transported via ZntB is not well understood. However, scientists have been able to speculate that the transport of Zn2+ is related to pH gradient and the electrostatics of the protein membrane.[3][4]

ZIP (SLC39)

Quick Facts Identifiers, Symbol ...

ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7 (Catsup), ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13, ZIP14

The structure of a bacterial ZIP protein has been resolved.[5]

References

  1. [1]
    Hara T, Takeda TA, Takagishi T, Fukue K, Kambe T, Fukada T (March 2017). "Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis". The Journal of Physiological Sciences. 67 (2): 283–301. doi:10.1007/s12576-017-0521-4. PMC 10717645. PMID 28130681.
  2. [2]
    Thomas P, Converse A, Berg HA (February 2018). "ZIP9, a novel membrane androgen receptor and zinc transporter protein". General and Comparative Endocrinology. 257: 130–136. doi:10.1016/j.ygcen.2017.04.016. PMID 28479083.
  3. [3]
    Gati C, Stetsenko A, Slotboom DJ, Scheres SH, Guskov A (November 2017). "The structural basis of proton driven zinc transport by ZntB". Nature Communications. 8 (1): 1313. Bibcode:2017NatCo...8.1313G. doi:10.1038/s41467-017-01483-7. PMC 5670123. PMID 29101379.
  4. [4]
    Tan K, Sather A, Robertson JL, Moy S, Roux B, Joachimiak A (October 2009). "Structure and electrostatic property of cytoplasmic domain of ZntB transporter". Protein Science. 18 (10): 2043–52. doi:10.1002/pro.215. PMC 2786968. PMID 19653298.
  5. [5]
    Zhang T, Liu J, Fellner M, Zhang C, Sui D, Hu J (August 2017). "Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway". Science Advances. 3 (8): e1700344. Bibcode:2017SciA....3E0344Z. doi:10.1126/sciadv.1700344. PMC 5573306. PMID 28875161.
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