Zeke is a masculine given name and nickname, sometimes a shortened form (hypocorism) of Ezekiel, which may refer to:

• Caleb Bailey (1898-1957), US Marine Corps brigadier general and athlete
• Zeke Bella (1930–2013), American baseball player
• Zeke Bonura (1908–1987), American baseball player
• Zeke Bratkowski (1931–2019), American football player
• Zeke Clements (1911–1994), American country musician
• Zeke Dombrowski (born 1986), American soccer player
• Ezekiel Elliott (born 1995), American football running back
• Ezekiel Emanuel (born 1957), American oncologist, bioethicist and professor
• Zeke Jabbour, American professional bridge player
• Zeke Jones (born 1966), American wrestler
• Zeke Manners (1911–2000), American country musician
• Zeke Manyika (born 1955), Zimbabwean-born British musician
• Zeke Meyer (1892–1962), American racecar driver
• Zeke Moore (American football) (born 1943), American football player
• Zeke Moore (basketball) (born 1997), Trinidadian-American basketball player
• Zeke Moreno (born 1978), American football player
• Zeke Mowatt (born 1961), American football player
• Zeke Nnaji (born 2001), American basketball player
• Alden Sanborn (1899–1991), American rower
• Zeke Smith (1936–2016), American football player
• Zeke Steggall (born 1971), Australian snowboarder
• Isiah Thomas (born 1989), American retired Hall-of-Fame basketball player
• Zeke Turner (born 1996), American football player
• Zeke Upshaw (1991–2018), American basketball player
• Zeke Vandenburgh (born 1999), American football player
• Zeke Wilson (1869–1928), American baseball player
• Zeke Wissinger (1902–1963), American football player
• Zeke Wrigley (1874–1952), American baseball player
• Zeke Zarchy (1915–2009), American trumpet player
• Zeke Zawoluk (1930–2007), American basketball player
• Zeke Zekley (1915–2005), American cartoonist
• Zeke Zettner (1948–1973), American musician