Windup_pain

Pain wind-up

Pain wind-up

Perception of pain

Pain wind-up is the increase in pain intensity over time when a given stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord (posterior horn) neurons due to priming of the NMDA receptor based response.[1][2] It describes an exponentially progressive increase in firing of WDR neurons with repeated stimulation.

References

  1. [1]
    Feng Xu; Tianjian Lu (29 May 2011). Introduction to Skin Biothermomechanics and Thermal Pain. Springer. p. 347. ISBN 978-3-642-13201-8. Retrieved 25 April 2012.
  2. [2]
    Pitcher and Henry (2000). Eur. J. Neurosci., 12:2006–2020.
Share this article:

This article uses material from the Wikipedia article Windup_pain, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.