William Poole (1821–1855), also known as "Bill the Butcher", was an American gang member and leader of the Know Nothing political movement

William Poole may also refer to:

• William Poole (Australian politician) (1828–1902), New South Wales politician
• William Poole (economist) (born 1937), American economist, former president of the Federal Reserve Bank of St. Louis
• William A. Poole (1831–1903), merchant and politician from Prince Edward Island, Canada
• William B. Poole (1833–1904), American sailor and Medal of Honor recipient
• William Frederick Poole (1821–1894), American bibliographer and librarian
• William H. Poole (politician), member of the California legislature
• William H. Poole (writer) (1820–1896), Canadian minister and writer
• William Henry Poole (1876–1921), college football player and minister
• William Henry Evered Poole (1902–1969), South African military commander and diplomat
• William Leslie Poole (1866–1931), English immigrant to Uruguay important to the development of association football in Uruguay
• William Mansfield Poole (1871–1946), educationalist and author
• William T. Poole, 20th-century American research analyst for the US Congress

• Bill Poole, American politician
• Will Poole (born 1981), American footballer
• William Wortham Pool (1842–1922), American bookkeeper

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