William, Bill, or Billy Matthews may refer to:

• William Matthews (politician) (1755–1808), American politician in Maryland
• Donald Ray Matthews (1907–1997), known as Billy, American congressman
• Bill Matthews (born 1947), Canadian politician

• Bill Matthews (footballer) (1876–1923), Australian footballer for St Kilda
• William Clarence Matthews (1877–1928), American baseball infielder and lawyer
• William Matthews (baseball) (1878–1946), American baseball pitcher
• Billy Matthews (footballer, born 1882) (1882–1916), English footballer
• Billy Matthews (footballer, born 1883) (1883–1921), Welsh footballer
• William Howard Matthews (1885–1963), English footballer
• Billy Matthews (footballer, born 1897) (1897–1987), Welsh footballer

• William Matthews (priest) (1770–1854), American Catholic priest and President of Georgetown College
• William D. Matthews (1827–1906), African American abolitionist, Civil War Union officer and Freemason
• William Matthews (engineer) (1844–1922), British civil engineer
• William E. Matthews (1845–1894), lawyer, financier, and civil rights activist
• William Matthews (poet) (1942–1997), American poet and essayist
• William Matthews (fl. 1970–1983), co-editor of the diary of Samuel Pepys
• William Matthews (musician) (born 1983), American musician
• William Matthews (bookbinder) (1822–1896), American bookbinder

• Billie Matthews (1930–2001), American football coach
• Will Matthews (disambiguation)
• William Mathews (disambiguation)
• All pages with titles containing William Matthews

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