William Holden (1918–1981) was an American film actor.

William Holden may also refer to:

• William Holden (character actor) (1862-1932), American actor
• William Holden (journalist) (1808–1897), writer for South Australian Register and Adelaide Observer
• William Woods Holden (1818–1892), governor of North Carolina
• William Holden (politician) (c.1824–1884), 11th Lieutenant Governor of California
• William Holden (cricketer) (1883-1949), New Zealand cricketer
• William Holden (footballer) (1860–?), English footballer
• Bill Holden (baseball) (1889–1971), American baseball player
• William Curry Holden (1898–1983), American archaeologist, museum curator and historian
• Bill Holden (footballer) (1928–2011), English footballer
• Bill Holden (schoolteacher) (born 1948), American schoolteacher and juvenile diabetes activist
• Bill Holden (speedway rider) (1923-2011), British speedway rider.
• Bill Holden (ice hockey) (born 1949), Canadian ice hockey player
• Will Holden (American football) (born 1993), American football offensive tackle
• Will Holden (EastEnders), EastEnders character

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