Orangeburg-Wilkinson High School is located in Orangeburg, South Carolina.

It is a part of the Orangeburg County School District. It is home to the Mighty Bruins/Bruinettes and also an International Baccalaureate World School.^[2]

Delano Middleton, a student at Wilkinson High School, was one of those killed in the Orangeburg Massacre.

Orangeburg-Wilkinson High School was formed with the merger of Orangeburg High School and Wilkinson High School in 1971.^[3]

In 2016, the school was featured in the six-part BBC documentary series Segregated America: A School in the South.^[4]

• Shelton Benjamin, professional wrestler signed to the WWE, was a 2x NCAA wrestling All-American at the University of Minnesota^[5]
• Marianna W. Davis, professor and author who wrote about black women^[6]
• Michael Hackett, professional basketball player^[7]
• Jaime Harrison, politician, chair of the South Carolina Democratic Party (2013–2017)^[8] and Democratic National Committee (2021–present)^[9]
• Mike O'Cain, American football coach^[10]
• Eugene Robinson, newspaper columnist and an associate editor of The Washington Post^[11]
• Bakari Sellers, politician ^[12]
• Mike Sharperson, MLB infielder and 2x World Series champion^[13]
• Herm Winningham, MLB player and 1990 World Series champion with the Cincinnati Reds^[14]
• Beverly Buchanan, artist