The eighth and final season^[1] of Weeds premiered on July 1, 2012, on the television cable network Showtime, and featured 13 episodes, bringing the series total to 102.^[2] It marks the return of the show's theme song, "Little Boxes". Creator Jenji Kohan revealed that cover versions of the song would be used during the opening credits (as during past seasons) and confirmed that Ben Folds and the Mountain Goats would be featured artists. Kohan also confirmed that the song would be covered in a duet by Steve Martin and series regular Kevin Nealon, who each sang and played the banjo.^[3] Series co-star Hunter Parrish also provided a cover version for the season's tenth episode.^[4] The final two episodes of the season aired back to back as a one-hour series finale, which was the series' first and only one-hour show in its eight-year run.

Season eight picks up where season seven ended—the family is eating dinner when a concealed sniper targets Nancy through a rifle scope and fires a shot. Nancy, shot in the head, is rushed to the hospital.^[3] While she is still unconscious, the shooter, Tim Scottson, son of her late second husband, DEA agent Peter Scottson, visits her. Shane, first a member of the police academy and later an officer, arrests him with his police squad. Nancy's estranged sister Jill sleeps with both Nancy's brother-in-law Andy and Doug. Subsequently, Jill claims to be pregnant but lies and is really going through menopause.

Nancy begins working as a representative at a pharmaceutical company which legally produces medical marijuana for people diagnosed with cancer undergoing radiation therapy. Silas also gets a job growing marijuana at the same company as Nancy. After Silas starts working at the pharmaceutical company, he finds himself not too pleased with the process his plants have to go through after they are selected. This leads him to contemplate what marijuana really means to him.

After much debate and deliberation, Nancy and Silas realize the industry in which they belong. This realization has them back in Regrestic (formerly Agrestic and Majestic, where the story began). Teaming up with past friends (and enemies) Nancy develops a scheme.

The series finale jumps several years into the future and shows how the lives of the characters have progressed. Marijuana was legalized at an unspecified time during the time jump and as a result the Botwins are running several successful marijuana businesses. Per usual, the series gives a slightly dark twist on the present lives of the characters. Nancy regrets her past, but knows there is nothing she can do to change it. Doug on the other hand, wants to reconcile his past mistakes. In the end, the main characters are huddled together, pondering and reflecting, while enjoying the product that has often caused them so much turmoil and yet made them closer and more appreciative of the unique bond they share.

Showtime officially renewed Weeds for an eighth season on November 10, 2011.^[2] Creator and showrunner Jenji Kohan alongside the other series producers convened for story meetings and were informed early on in the writing process that Showtime Entertainment President David Nevins would not be renewing the show for a ninth season.^[3] "It did change how we talked about the season so far. We're building toward something different than we might have built toward had we been in the dark," commented Kohan.^[3]

For the first time since the fourth season, the show featured the Malvina Reynolds song Little Boxes as its theme music, along with a new opening title sequence. The original title sequence was briefly revived in episode 11 with the notable difference of signs reading Regrestic rather than Agrestic and Majestic. Like seasons two and three, different bands and artists were used to cover the song for each episode.^[3] Moreover, Julie Anne Robinson, who had not directed an episode since season four, directed two episodes this season. In addition, Perry Lang, who had not directed an episode since season three, directed an episode this season.

The season's first episode, "Messy", was made available online through Showtime's "Freeview" Facebook page a week before the broadcast premiere.^[17]

This season earned 57 out of 100 on Metacritic, indicating mixed reviews.^[18]