The Wapanocca National Wildlife Refuge is a 5,484 acre (22 km²) wildlife refuge in Crittenden County, Arkansas, managed by the United States Fish and Wildlife Service.

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Wapanocca National Wildlife Refuge
IUCN category IV (habitat/species management area)
Map of the United States
Location	Crittenden County, Arkansas, United States
Nearest city	Turrell, Arkansas
Coordinates	35°20′45″N 90°13′00″W
Area	5,484 acres (22.19 km2)
Established	1961
Governing body	U.S. Fish and Wildlife Service
Website	Wapanocca National Wildlife Refuge

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Wapanocca National Wildlife Refuge was established in 1961 from land acquired from the former "Wapanocca Outing Club" which was a prestigious hunting club formed in 1886. The refuge is located 3 miles (5 km) west of the Mississippi River near the city of Turrell, Arkansas.

The refuge was once a bend in the Mississippi River. It is a migration stopover for warblers and other neo-tropical birds. The refuge is host to the blue heron, and the common egret as well as the bald eagle. The refuge is a major stopover on the Mississippi Flyway. Wapanocca consists of 600 acres (2.4 km²) of open water, 1,800 acres (7 km²) of swampland, 500 acres (2.0 km²) of bottomland hardwood, 1,200 acres (4.9 km²) of cropland, and 400 acres (1.6 km²) of grassland.