Vav_(protein)
Vav (protein)
Proteins involved in cell signalling
Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family.[1][2] GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms,[1] Vav family proteins have been observed in Choanoflagellates.[2]