USS Key West has been the name of three ships in the United States Navy.

• USS Key West (1862), was a steamship used by the Union Navy during the American Civil War
• USS Key West (PF-17), was a Tacoma-class frigate launched in 1943 and scrapped in 1947
• USS Key West (SSN-722), is a Los Angeles-class submarine currently in service

• USS Key (DE-348), a John C. Butler-class destroyer escort launched in 1943 and broken up in 1972

This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.