USS Charleston may refer to:

• USS Charleston (1798), a galley in commission from 1798 to 1802
• USS Charleston (C-2), a protected cruiser commissioned in 1889 and wrecked in 1899
• USS Charleston (C-22), a protected cruiser in commission from 1905 to 1923
• USS Charleston (PG-51), a gunboat in commission from 1936 to 1946
• USS Charleston (LKA-113), an amphibious cargo ship in commission from 1968 to 1992
• USS Charleston (LCS-18), a littoral combat ship commissioned on March 2, 2019

• On the Beach (2000 film)

This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.