UDP-galactose

Uridine diphosphate galactose

Uridine diphosphate galactose

Chemical compound


Uridine diphosphate galactose (UDP-galactose) is an intermediate in the production of polysaccharides.[1] It is important in nucleotide sugars metabolism, and is the substrate for the transferase B4GALT5.

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Sugar metabolism

UDP-Galactose is especially relevant in glycolysis. It is derived from galactose an epimer of glucose, and via the Leloir Pathway, it is used be used as a precursor for the metabolism of glucose into pyruvate.[2] When lactose is hydrolyzed, D-Galactose enters the liver via the bloodstream. There, galactokinase phosphorylates it to galactose-1-phosphate using ATP. This compound then engages in a "ping-pong" reaction with UDP-Glucose, catalyzed by uridylyltransferase, yielding glucose-1-phosphate and UDP-Galactose. This glucose-1-phosphate feeds into glycolysis, while UDP-Galactose undergoes epimerization to regenerate UDP-Glucose.[3]

transforming galatose (1) to glucose for the glycolysis. Galactose-1-phosphate (2), UDP-glucose (3), UDP-galatose (4) ; Glucose 1-phosphate (5); Glucose 6-phosphate (6). Galactokinase (GK), Galactose-1-phosphate uridylyltransferase (GALT), UDP-glucose 4-epimerase (UGE), phosphoglucomutase (PGM)

See also


References

  1. Los, E.; Ford, G. A. (2022). "Galactose 1 Phosphate Uridyltransferase Deficiency". StatPearls. StatPearls. PMID 28722986.
  2. Garrett, Reginald H.; Grisham, Charles M. (2017). Biochemistry (6th ed.). Boston, MA, USA: Cengage Learning. ISBN 978-1-305-57720-6.
  3. Nelson, David L.; Cox, Michael M.; Nelson, David L. (2013). Lehninger, Albert L. (ed.). Lehninger principles of biochemistry (6th ed.). Basingstoke: Macmillan Higher Education. ISBN 978-1-4292-3414-6.




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