Trans-2-enoyl-CoA_reductase_(NADPH)

Trans-2-enoyl-CoA reductase (NADPH)

Trans-2-enoyl-CoA reductase (NADPH)

Class of enzymes

In enzymology, a trans-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.38) is an enzyme that catalyzes the chemical reaction

trans-2,3-dehydroacyl-CoA + NADPH + H+ acyl-CoA + NADP+
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Thus, the three substrates of this enzyme are trans-2,3-dehydroacyl-CoA, NADPH, and H+, whereas its two products are acyl-CoA and NADP+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ trans-2-oxidoreductase. Other names in common use include NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, and trans-2-enoyl-CoA reductase (NADPH). This enzyme participates in fatty acid elongation in mitochondria and polyunsaturated fatty acid biosynthesis.

References

    • Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H (November 1982). "Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli". Journal of Biochemistry. 92 (5): 1649–54. doi:10.1093/oxfordjournals.jbchem.a134091. PMID 6759504.


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