Trans-2-enoyl-CoA_reductase_(NAD+)

Trans-2-enoyl-CoA reductase (NAD+)

Trans-2-enoyl-CoA reductase (NAD+)

Class of enzymes


In enzymology, a trans-2-enoyl-CoA reductase (NAD+) (EC 1.3.1.44) is an enzyme that catalyzes the chemical reaction

trans-2,3-dehydroacyl-CoA + NADH + H+ acyl-CoA + NAD+

Thus, the three substrates of this enzyme are trans-didehydroacyl-CoA, NADH, and H+, whereas its two products are acyl-CoA and NAD+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NAD+ trans-2-oxidoreductase. This enzyme is also called trans-2-enoyl-CoA reductase (NAD+). This enzyme participates in butanoate metabolism.


References

    • Inui H, Miyatake K, Nakano Y, Kitaoka S (October 1986). "Purification and some properties of short chain-length specific trans-2-enoyl-CoA reductase in mitochondria of Euglena gracilis". J. Biochem. 100 (4). Tokyo: 995–1000. PMID 3102464.



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