The Tom Brady–Peyton Manning rivalry was a series of games that took place between 2001 and 2015 involving two quarterbacks in the National Football League (NFL): Tom Brady and Peyton Manning.^[1][2][3] It is considered by many to be the greatest individual NFL rivalry of all time, and has been compared to other legendary sports rivalries, such as Magic-Bird in basketball, Ali-Frazier in boxing, and Messi-Ronaldo in association football.

Both quarterbacks are considered to be among the greatest in NFL history. Brady won seven Super Bowl championships in his career (as well as five Super Bowl MVPs), while Manning won two Super Bowl championships (and one Super Bowl MVP) in his career. ^[4] Contrarily, Manning would go on to win five MVP awards in his 18-year career, while Brady would win three in his 22-year career. Both quarterbacks also made the Pro Bowl fourteen or more times in their careers,^[5] and both were selected to the NFL 100th Anniversary All-Time Team in 2019. Brady and Manning are the only starting quarterbacks to win Super Bowls with multiple franchises, and are believed by many as the best NFL players of the 2000s and 2010s.^{[6][7][8][9][10][11][12][13]}

Tom Brady played for the New England Patriots from 2000, when he was the 199th selection in the sixth round of the 2000 NFL draft, through 2019.^[14] After Drew Bledsoe was injured in week 2 of the 2001 season, Brady got his first career start against Peyton Manning's Indianapolis Colts, winning the game 44–13.^[15] Brady was the Patriots' starting quarterback until the team's final game of the 2019 season, with the exception of 2008, when he tore his ACL in the opening game, and 2016, when he was suspended for the first four games of the season due to his alleged involvement in the Deflategate scandal. Brady appeared in a record ten Super Bowls (nine with the Patriots, one with the Tampa Bay Buccaneers) and has won a record seven (six with the Patriots, one with the Buccaneers).

Manning was drafted by the Colts in the 1998 NFL draft as the number 1 pick, and played for the Colts until the team's final game of the 2010 season, as a neck injury caused him to miss the entire 2011 season. The Colts finished 2–14 that year in his absence and secured the #1 pick in the draft where he became expendable once consensus top prospect, quarterback Andrew Luck of Stanford, was available. During his time with the Colts, Manning led them to two Super Bowls, winning one.^[16] On March 20, 2012, after fourteen years with the Colts, Manning signed with the Denver Broncos, for whom he played until his retirement following the 2015 season. He led the Broncos to two Super Bowl appearances, winning Super Bowl 50 in what would be his final game. Like Brady, Manning led his new team to their first Super Bowl win in nearly two decades.

Manning and Brady played each other seventeen times,^[18] with Brady winning the head-to-head series 11–6. From 2001 to 2015, the two quarterbacks met at least once every season, except 2002, 2008, and 2011; while Brady's Patriots and Manning's Colts played each other in 2008 and 2011, Brady missed the 2008 season and Manning missed the 2011 season, both due to injuries (Brady with an ACL tear suffered Week 1 and Manning with neck problems). The two quarterbacks did not meet during the 2015 regular season (Brady's Patriots did play Manning's Broncos, but Manning missed the game due to a plantar fasciitis injury), though they met in that year's AFC Championship Game.

Brady won the Colts–Patriots series 8–4^[19] and also won the Broncos–Patriots series 3–2, though Manning's two wins with the Broncos both occurred in the AFC Championship Games in 2013 and 2015. Brady led the series in Foxborough 8–2, while Manning led the series in Indianapolis/Denver 4–3.^[20]

The two quarterbacks met five times in the NFL Playoffs, in which Manning won three of them (all five were won by the home team, as Brady's two wins both came in Foxborough). Four of the five match-ups were in the AFC Championship Game, with Manning winning three of the four, one of the games with the Colts (2006) and another two with the Broncos (2013, 2015). The winner of each of the playoff match-ups went on to represent the AFC in the Super Bowl. Four of the teams, Brady's 2003 and 2004 Patriots and Manning's 2006 Colts and 2015 Broncos went on to win the Super Bowl, while Manning's 2013 Broncos lost the game.