Thomas Mayne may refer to:

• Thomas Mayne (politician) (1832–1915), Member of Parliament (MP) for Mid Tipperary, 1885–1890
• Thomas Mayne (inventor) (1901–1995), Australian industrial chemist, inventor of the Nestlé drink Milo
• Thomas Mayne, MP for Newcastle-under-Lyme

• Thom Mayne (born 1944), American architect
• Thomas Mayne Reid (1818–1883), Irish-American novelist

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