The day after the latest Extermination, Charlie, the princess of Hell, pursues her seemingly impossible goal of rehabilitating demons to peacefully reduce overpopulation in Hell. She opens a hotel in hopes that patients will be "checking out" into Heaven. While most of Hell mocks her goal, her devoted girlfriend, Vaggie, and their first test subject, adult film star Angel Dust, stick by her side. When Alastor, a powerful entity known as "The Radio Demon", reaches out to Charlie to assist in her endeavors, her crazy dream is given a chance to become a reality.^[11]

Musical numbers: "I'm Always Chasing Rainbows", "Inside of Every Demon Is a Rainbow", and "Alastor's Reprise"

Taking place one week after the events of the pilot, Charlie reveals in a backstory that Lucifer was originally an angel that fell in love with Lilith, the first woman. They gave the second woman, Eve, the gift of free will, inadvertently creating Hell, where Lucifer and Lilith were banished to by Heaven. To ensure the sinners of Hell don't rebel, several angels create the annual Extermination to keep them in line. As Hell is still recovering from the last Extermination, Charlie mentions that she has not seen or heard from Lilith in seven years. Later, Charlie receives a call from her father asking her to take his place in his annual meeting with Heaven. Charlie pitches to Adam - leader of the Exterminations of Hell - and his second-in-command Lute, her plan to save sinners through redemption in her hotel. Her pitch is ignored and laughed at, and Adam tells her that the next Extermination will happen in six months rather than a year. Meanwhile, Vaggie, Charlie's girlfriend, enlists the staff of the hotel to make a commercial to promote the hotel, but the final product is cut short by a news broadcast announcing the Extermination date being moved. Lute finds the corpse of an exterminator killed in Hell and shows Adam, and the two plan to kill every demon in Hell during the next Extermination.

Musical numbers: "Happy Day in Hell" and "Hell is Forever"

When a trio of powerful overlords known as the Vees (Vox, Valentino, and Velvette) find out that Alastor, another overlord, is back after being gone for seven years, Vox tries to send a warning to him. This backfires when Alastor sends his own warning to Vox. The Vees then decide to try to destroy the hotel from the inside. Vox enlists a demon named Sir Pentious to spy on the hotel by posing as a guest. As Sir Pentious is getting adjusted to the operations of the hotel, Angel Dust, another resident of the hotel and Hell's most popular porn star, feels saddened that Charlie doesn't believe he can change. Angel Dust later finds out that Sir Pentious is working for Vox, and shows Charlie and Vaggie proof. Although Angel Dust and Vaggie want to kill Sir Pentious, Charlie forgives him and gives him a second chance after witnessing Vox yell at him for failing. Sir Pentious apologizes for his deceit and decides to become a true patron at the hotel.

Musical numbers: "Stayed Gone" and "It Starts With Sorry"

To help Sir Pentious improve as a person, Vaggie insists that he gets rid of his egg minions, whom he refers to as his "Egg Bois", much to Pentious' dismay. She asks Alastor to get rid of them, but before he can, he runs into Zestial, an ancient overlord, who invites him to a meeting for the overlords of Hell. During the meeting, Velvette shows the other overlords the head of the dead exterminator angel, suggesting they go to war with Heaven. This idea is shot down by Zestial, who fears a war between Heaven and Hell would lead to more deaths. Velvette insults Zestial but is kicked out by Carmilla Carmine, an overlord who controls Hell's weapon supplies. Carmilla reveals to Zestial that she killed the exterminator to protect her daughters, which is overheard by one of Sir Pentious’ Egg Bois. The egg relays the message to Alastor. Meanwhile, Charlie asks Vaggie to lead trust exercises at the hotel. Vaggie worries that the group won't be ready when the next Extermination happens, and pushes the patrons to take part in strenuous activities. However, when Charlie tells Vaggie she feels that Vaggie is going too far in her methods, the two talk it out and discover their friends bonded over the experiences Vaggie put them through. In the end, Charlie and Vaggie let Sir Pentious keep his Egg Bois.

Musical numbers: "Respectless" and "Whatever It Takes"

Angel Dust leaves the hotel to act in a porn film for his boss, Valentino. While shooting, Charlie arrives and tries to bring Angel Dust back to the hotel, but Valentino beats Angel Dust, reminds him that he owns Angel Dust's soul, and forces him to make her leave. Angel Dust continues filming and is constantly assaulted by Valentino and other workers. When he gets back to the hotel, he gets into an argument with Husk, the hotel bartender, who had earlier accused him of being "fake". Angel Dust leaves to go to a bar, unknowingly followed by Husk at Charlie's insistence. Husk saves Angel Dust from being drugged by one of Valentino's workers, but Angel Dust lashes out at him for saving him, revealing that he purposely lets Valentino assault him so that when he is broken and ruined, Valentino will stop using him. Husk reveals that he was once an overlord whose gambling addiction led him to make a deal with Alastor to keep his power, trapping him in a similar situation to Angel Dust. Realizing they share the collective experience, the two form a friendship. Arriving back at the hotel, Angel Dust thanks Charlie for caring about him, making her emotional.

Musical numbers: "Poison" and "Loser, Baby"

Charlie spends all night trying to figure out a way to reconnect with Heaven. Left with no other options, she calls her father, Lucifer. He shows up at the hotel and isn't impressed, clashing with Alastor. They are interrupted when Alastor's friend Mimzy barges in, wanting to meet with Alastor. Husk is distrustful of Mimzy, claiming that she only shows up when she needs something. Alastor brushes him off, but when Husk hints at Alastor owing a debt to someone, Alastor loses his temper and threatens to kill Husk if he steps out of line again. Husk's suspicions about Mimzy are later revealed to be true, as several loan shark demons attack the hotel in an attempt to find her. Alastor uses his powers to kill the loan sharks before forcing Mimzy to leave, not wanting the hotel to be damaged further. Lucifer reveals that he believes Charlie's plan is impossible because sinners are inherently evil and that Heaven will never listen to her. This upsets Charlie, but they ultimately reconcile, and Lucifer agrees to arrange Charlie another meeting with Heaven.

Musical numbers: "Hell's Greatest Dad" and "More Than Anything"

Charlie and Vaggie arrive in Heaven for a trial intended to decide whether souls in Hell can be redeemed. They are welcomed by Sera, the head seraphim, and Emily, a younger seraphim. Adam and Lute confront Vaggie, who is revealed to be a former exterminator angel who was stripped of her wings and left eye by Lute after sparing a defenseless sinner child. Adam threatens to tell Charlie if Vaggie does not sabotage the trial. The trial begins by monitoring Angel Dust's actions as his friend Cherri Bomb takes him and the other hotel members to a nightclub. While trying to save Niffty, the hotel maid, from Valentino, Angel Dust stands up to him, saying that Valentino can do whatever he wants to him in the studio, but Angel Dust is his own man away from the studio. Charlie claims this is proof of Angel Dust being redeemable, but it's revealed that the angels themselves don't know how souls enter Heaven. While arguing over the case, Adam accidentally reveals the Extermination plans, causing Emily to distrust Sera, as Sera knew about the plans and didn't tell her. Adam also tells Charlie about Vaggie's past as an exterminator, which leaves Charlie distraught. The court finds that there is no evidence a sinner can be redeemed. Adam sends Charlie and Vaggie back to Hell, promising them that when the next Extermination begins in a month, he'll be coming for the hotel first. Emily vows to help Charlie.

Musical numbers: "Welcome to Heaven" and "You Didn't Know"

After they are kicked out of Heaven, Vaggie reveals to the rest of the group that she was once an angel. Alastor, taking advantage of Charlie's fragile mental state, convinces her to make a deal with him. In exchange for an unknown favor she will do for him later, he tells her that there is a way to kill exterminators and that Carmilla Carmine knows how. Charlie tells Vaggie to go to Carmilla to convince her to help, while Charlie and Alastor seek other sinners to help them fight. Charlie and Alastor go to Cannibal Town and meet Rosie, the overlord who runs the town. Rosie and eventually the rest of the cannibals agree to help fend off the angels. Rosie convinces Charlie that Vaggie is being redeemed through the hotel. Meanwhile, Carmilla teaches Vaggie how to fight angels and tells her that she killed the exterminator using angelic weaponry scavenged from past Exterminations. Vaggie regains her wings and Carmilla agrees to help the hotel by supplying them with angelic weapons. Vaggie and Charlie return to the hotel and reconcile with each other. Upon entering the hotel, they are shocked to see the staff readying themselves for the battle with the angels.

Musical numbers: "Out For Love" and "Ready for This"

As the inhabitants of the hotel reinforce the hotel, Charlie shares with Vaggie her worries that she has led everyone to their deaths, though Vaggie convinces her to believe in herself. Extermination Day arrives and an all-out war between the angels and sinners ensues. Alastor and Adam fight, with Adam badly wounding Alastor and forcing him to flee. Sir Pentious confesses his love for Cherri Bomb, before sacrificing himself in a failed attempt to destroy Adam. Distraught and enraged over Sir Pentious's death, Charlie enters her full demon form and confronts Adam while Vaggie is forced to fight Lute. Vaggie crushes Lute under some rubble and spares her, but Lute tears her arm off to escape the rubble and continues attacking Vaggie. Lucifer arrives to help Charlie and easily overpowers Adam, who destroys the hotel before being killed by Niffty. Lute and the other angels retreat, and Charlie rebuilds the hotel to a greater state alongside her friends and father. As the Vees plot to take over Hell, Alastor hopes for freedom from a previous deal and control over Hell, before reuniting with Charlie and her friends. Sir Pentious manifests in Heaven as an angel, proving that sinners can be redeemed. Lute, now in charge of the Exterminations, confronts Lilith in Heaven, telling her that if she wants to stay there, she has to stop Charlie.

Musical numbers: "More Than Anything (Reprise)" and "Finale"