In neurobiology, a tetanic stimulation consists of a high-frequency sequence of individual stimulations of a neuron.^{[citation needed]} It is associated with potentiation.

High-frequency stimulation causes an increase in release called post-tetanic potentiation (Kandel 2003).^{[citation needed]} This presynaptic event is caused by calcium influx. Calcium-protein interactions then produce a change in vesicle exocytosis. The result of these changes is to make the postsynaptic cell more likely to fire an action potential.

Tetanic stimulation is used in medicine to detect a non-depolarizing block or a depolarizing block on the neuromuscular junction.^[1] Lower elicitations of tetanic stimulation in aged muscles were shown to be caused by lower levels of anaerobic energy provision in skeletal muscles.

• Hebbian theory