In enzymology, a tartrate dehydrogenase (EC 1.1.1.93) is an enzyme that catalyzes the chemical reaction

tartrate + NAD⁺ ${\displaystyle \rightleftharpoons }$ oxaloglycolate + NADH + H⁺

Thus, the two substrates of this enzyme are tartrate and NAD⁺, whereas its 3 products are oxaloglycolate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is tartrate:NAD⁺ oxidoreductase. This enzyme is also called mesotartrate dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, manganese.