TIE-1
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[5]
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Quick Facts tyrosine kinase with immunoglobulin-like and EGF-like domains 1, Identifiers ...
tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |||||||
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Identifiers | |||||||
Symbol | TIE1 | ||||||
Alt. symbols | TIE, JTK14 | ||||||
NCBI gene | 7075 | ||||||
HGNC | 11809 | ||||||
OMIM | 600222 | ||||||
RefSeq | NM_005424 | ||||||
UniProt | P35590 | ||||||
Other data | |||||||
EC number | 2.7.1.112 | ||||||
Locus | Chr. 1 p34-p33 | ||||||
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TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[6] and platelets.[7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[8]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.
- Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.
- Receptor,+TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)