In Belize, the Thomas Vincent Ramos Highway takes up where the Hummingbird Highway ends and runs from Dangriga to Punta Gorda.^[1] It is entirely paved, with the completion of a 10-mile segment between Golden Stream and Big Falls circa 2008–09. The TV Ramos Highway provides important access to a number of Mayan ruins and natural areas. The ancient Mayan sites of Nim Li Punit and Lubaantun are each situated a few miles west of the highway in southern Belize. The Cockscomb Basin Wildlife Sanctuary is several miles west of the highway in south-central Belize.^[2]

In 2011, a project was initiated, and complete by 2015, to extend the Southern Highway 21.4 mi/34.5 km to Jalacte in southwestern Belize.^[3]

On September 30, 2020 the Southern Highway was renamed to Thomas Vincent Ramos Highway. It was named after Thomas Vincent Ramos, the creator of Garifuna Settlement Day.^[4]