Soluble_low-density_lipoprotein_receptor-related_protein

Soluble low-density lipoprotein receptor-related protein

Soluble low-density lipoprotein receptor-related protein

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Soluble low-density lipoprotein receptor-related protein (sLRP, LRP-515) is a biological substance naturally produced by the human body.[1][2] This protein has been found to bind to and neutralize anywhere from 70 to 90 percent of the amyloid-beta peptide that also naturally circulates in healthy human or mouse plasma.[3] Impairment of this function is strongly associated with, and may soon be shown definitively to be the principal cause of, Alzheimer's disease.[4]

References

  1. [1]
    Quinn KA, Pye VJ, et al. (1999). "Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP)". Exp. Cell Res. 251 (2): 433–441. doi:10.1006/excr.1999.4590. PMID 10471328.
  2. [2]
    Quinn KA, Grimsley PG, et al. (1997). "Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma". J. Biol. Chem. 272 (38): 23946–23951. doi:10.1074/jbc.272.38.23946. PMID 9295345.
  3. [3]
    "Draining away brain's toxic protein to stop Alzheimer's". Retrieved 2007-10-25.
  4. [4]
    Sagare A, Deane R, et al. (2007). "Clearance of amyloid-beta by circulating lipoprotein receptors". Nat. Med. 13 (9): 1029–1031. doi:10.1038/nm1635. PMC 2936449. PMID 17694066.
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