Silicone-induced_granulomatous_inflammation
Silicone granuloma
Medical condition
Silicone granulomas are a skin condition that occur as a reaction to liquid silicones, and are characterized by the formation of nodules.[1]: 46
Silicone granuloma | |
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Snowball like hyperechogenic axillary lymph nodes in a woman with silicone implants removed due to complications | |
Specialty | Dermatology |
Formation of a granuloma is a common tissue response to a range of foreign bodies. Silicone can be directly injected into tissue as part of a cosmetic procedure or it can leak from silicone implants. The formation and consequences of silicon-induced granulomas is not well described or understood. The extent of damage that they cause is controversial.[2]
Silicone-induced granuloma can be associated with fever,[12] calcitriol-mediated hypercalcemia,[13] reactive amyloidosis.[14][15][16]
Treatment of silicone granulomas and removal of unwanted silicone have historically been very challenging. Anti-inflammatory agents (e.g., oral corticosteroids, allopurinol, colchicine, isotretinoin, cyclosporine, imiquimod, antibiotics) may help treat the granulomatous inflammation,[17] but do not address or remove the underlying source silicone material. Surgical excision allows for removal of the underlying source of inflammation, but is often deferred due to associated scarring.[18]
More recently, a case of successful removal of injected silicone using microcoring technology was reported, providing a potential scar-less option for its removal.[18]
- James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
- Péoc'h, M; Duprez, D; Grice, G; Fabre-Bocquentin, B; Gressin, R; Pasquier, B (2000). "Silicone lymphadenopathy mimicking a lymphoma in a patient with a metatarsophalangeal joint prosthesis". Journal of Clinical Pathology. 53 (7): 549–51. doi:10.1136/jcp.53.7.549. PMC 1731232. PMID 10961180.
- García Callejo, F. J.; Calvo González, J; Agustí Martínez, J; Bécares Martínez, C; Monzó Gandía, R; Marco Algarra, J (2013). "Neck lymphadenitis due to silicone granuloma after mammary implants". Acta Otorrinolaringológica Española. 64 (3): 217–22. doi:10.1016/j.otorri.2012.12.003. PMID 23499209.
- Rieder, E; Desai, S; Mundi, J. P.; Boyd, K. P.; Patel, R. R.; Ramachandran, S; Franks Jr, A. G. (2013). "Granulomatous dermatitis related to silicone implant". Dermatology Online Journal. 19 (12): 20708. doi:10.5070/D31912020708. PMID 24364999.
- El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 1–3. doi:10.1155/2011/129138. PMC 3505939. PMID 23198167.
- Schwartzfarb, E. M.; Hametti, J. M.; Romanelli, P; Ricotti, C (2008). "Foreign body granuloma formation secondary to silicone injection". Dermatology Online Journal. 14 (7): 20. doi:10.5070/D37JX780XV. PMID 18718204.
- El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 1–3. doi:10.1155/2011/129138. PMC 3505939. PMID 23198167.
- Symmers, W. S. (1968). "Silicone mastitis in "topless" waitresses and some other varieties of foreign-body mastitis". British Medical Journal. 3 (5609): 19–22. doi:10.1136/bmj.3.5609.8-a. PMC 1989508. PMID 5690841.
- Agrawal, N; Altiner, S; Mezitis, N. H.; Helbig, S (2013). "Silicone-induced granuloma after injection for cosmetic purposes: A rare entity of calcitriol-mediated hypercalcemia". Case Reports in Medicine. 2013: 1–3. doi:10.1155/2013/807292. PMC 3864076. PMID 24363673.
- d'Ythurbide, G; Kerrou, K; Brocheriou, I; Hertig, A (2012). "Reactive amyloidosis complicated by end-stage renal disease 28 years after liquid silicone injection in the buttocks". BMJ Case Reports. 2012: bcr2012006803. doi:10.1136/bcr-2012-006803. PMC 4543521. PMID 23035166.
- Pérez-Ruiz, Carmen; Barabash-Neila, Román; Zulueta-Dorado, Teresa; Conejo-Mir Sánchez, Julián (March 2019). "Adverse Granulomatous Reaction to Silicone Filler Treated With Methotrexate". Dermatologic Surgery. 45 (3): 489–492. doi:10.1097/DSS.0000000000001574. ISSN 1076-0512.
- Hashemi, David A.; Tao, Joy; Wang, Jordan V.; Geronemus, Roy G. (2024-01-04). "Injected Silicone Removed Using Dermal Microcoring". Dermatologic Surgery. doi:10.1097/DSS.0000000000004068. ISSN 1076-0512.
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