Semisquaric_acid

Moniliformin

Moniliformin

Chemical compound

Moniliformin is an unusual mycotoxin, a feed contaminant that is lethal to fowl, especially ducklings.

Quick Facts Names, Identifiers ...

Moniliformin is formed in many cereals by a number of Fusarium species that include Fusarium moniliforme, Fusarium avenaceum, Fusarium subglutinans, Fusarium proliferatum, Fusarium fujikuroi and others. It is mainly cardiotoxic and causes ventricular hypertrophy. Moniliformin actually causes competitive inhibition of the activity of pyruvate dehydrogenase complex of respiratory reaction, which prevents pyruvic acid, product of glycolysis, to convert to acetyl-CoA.[1][2][3] Ultrastructural examination of right ventricular wall of 9 month old female mink (Mustela vison) fed acute doses of moniliformin (2.2 and 2.8 mg/kg diet) and sub-acute doses (1.5 to 3.2 mg/kg diet) reveals significant damage to myofiber, mitochondria, Z and M lines and sarcoplasmic reticulum as well as increased extracellular collagen deposition.[clarification needed] Minks are considered most sensitive mammals to the toxicity of moniliformin.[4] Chemically speaking, it is the sodium salt of deoxysquaric acid (the other name of that acid is semisquaric acid).

Physicochemical information

Moniliformin is soluble in water and polar solvents, such as methanol.

λmax: 226 nm and 259 nm in methanol.

See also

Sources and references

  1. [1]
    Thiel, Pieter G (1978). "A molecular mechanism for the toxic action of moniliformin, a mycotoxin produced by fusarium moniliforme". Biochemical Pharmacology. 27 (4): 483–6. doi:10.1016/0006-2952(78)90381-7. PMID 629807.
  2. [2]
    Moniliformin product page from Fermentek
  3. [3]
    Moniliformin information leaflet by Romerlab
  4. [4]
    Morgan MK, Fitzgerald SD, Rottinghaus GE, Bursian SJ and Aulerich RJ. 1999. Toxic effects to mink of moniliformin extracted from Fusarium fujikuroi culture material. Veterinary and Human Toxicology 1(1):pp-1-5
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